- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Zebrafish FANCM Antibody / Fanconi Anemia Complementation Group M Protein Antibody is designed for the detection and study of FANCM, a highly conserved DNA repair factor that plays an essential role in maintenance of genome stability. FANCM is a key component of the Fanconi anemia DNA repair pathway and functions in the recognition and processing of DNA structures that arise during replication stress and DNA damage. Through these activities, FANCM helps preserve chromosome integrity and supports faithful transmission of genetic information during cell division.
Fanconi Anemia Complementation Group M Protein participates in cellular pathways that monitor genome integrity and coordinate responses to DNA damage. The protein possesses DNA translocase activity and contributes to stabilization of replication forks, processing of abnormal DNA structures, and recruitment of repair complexes to sites of genomic stress. These functions are critical for preventing accumulation of DNA lesions and maintaining normal cellular viability.
Zebrafish provide a valuable vertebrate model for investigating DNA repair mechanisms, developmental biology, and genome maintenance pathways. Because rapidly dividing embryonic tissues require efficient repair systems to preserve genomic integrity, FANCM-dependent pathways play important roles during vertebrate development. Studies in zebrafish have helped advance understanding of how DNA repair networks coordinate cellular proliferation, differentiation, and tissue formation while protecting the genome from replication-associated damage.
Beyond developmental biology, FANCM has attracted significant interest in research involving chromosome stability, replication stress, cancer biology, and inherited DNA repair disorders. The Fanconi anemia pathway serves as a central guardian of genome integrity, and FANCM remains an important target for investigations examining how cells detect, respond to, and repair DNA damage. Its role at the intersection of DNA replication and DNA repair has established FANCM as a widely studied regulator of genomic maintenance.
Zebrafish FANCM Antibody is useful for investigating DNA repair pathways, genome stability mechanisms, replication stress responses, and vertebrate developmental biology. Researchers utilize FANCM expression studies to better understand molecular processes governing chromosome maintenance, DNA damage responses, and preservation of genomic integrity during development and cellular proliferation.
This Zebrafish antibody is part of a broader Zebrafish / Danio rerio antibody panel offered by NSJ Bioreagents.
The optimal working dilution of the Zebrafish FANCM Antibody / Fanconi Anemia Complementation Group M Protein Antibody should be determined empirically by the investigator.
An E.coli-derived Zebrafish Fanconi Anemia Complementation Group M Protein recombinant protein (amino acids D222-Q1491) was used as the immunogen for the Zebrafish FANCM Antibody.
After reconstitution, the Zebrafish FANCM Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Zebrafish FANCM Antibody, Zebrafish Fanconi Anemia Complementation Group M Protein Antibody, Zebrafish DNA Repair Protein Antibody, Zebrafish Genome Maintenance Protein Antibody, Zebrafish Replication Stress Response Protein Antibody, Zebrafish Fanconi Anemia Pathway Protein Antibody, Zebrafish DNA Damage Response Protein Antibody
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