- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Zebrafish EPHA2 Antibody / Eph Receptor A2a Antibody (RZ1455)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RZ1455 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 539 |
|
| Species Reactivity | Zebrafish |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Buffer | Lyophilized from a buffered saline solution containing 2% trehalose. Reconstitute with 0.2 mL distilled water to yield a final antibody concentration of 500 ug/mL. |
| UniProt | Q6NZS1 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This Zebrafish EPHA2 Antibody / Eph Receptor A2a Antibody is available for research use only. |
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Zebrafish EPHA2 Antibody / Eph Receptor A2a Antibody recognizes EPHA2A, a member of the Eph family of receptor tyrosine kinases that mediates cell-cell communication through interactions with membrane-bound ephrin ligands. Eph receptor A2a is the zebrafish ortholog of human EPHA2 and plays important roles in regulating cell adhesion, migration, proliferation, and tissue organization during embryonic development. Through bidirectional signaling with ephrin-A ligands, EPHA2A helps establish tissue boundaries and coordinate cell positioning required for normal morphogenesis.
EPHA2A belongs to the largest family of receptor tyrosine kinases and contains extracellular ligand-binding domains, a transmembrane region, and an intracellular kinase domain that initiates downstream signaling pathways. Activation of Eph receptor A2a influences Rho family GTPases, MAPK, PI3K/AKT, and Src signaling cascades, resulting in changes in cytoskeletal dynamics and cellular behavior. In zebrafish, EPHA2A contributes to epithelial organization, neural patterning, angiogenesis, and organ development. Following the teleost genome duplication event, zebrafish possess epha2a and epha2b paralogs, which may exhibit both overlapping and specialized functions.
Eph receptor signaling is essential for contact-dependent cell communication and has been implicated in numerous developmental processes including axon guidance, somitogenesis, vascular remodeling, and tissue regeneration. Zebrafish provide an excellent vertebrate model for studying these pathways because of their optical transparency and genetic tractability. Analyses of EPHA2A signaling in zebrafish have improved understanding of epithelial morphogenesis and the mechanisms controlling cell migration and tissue architecture.
In humans, dysregulation of EPHA2 signaling has been associated with cancer progression, metastasis, cataracts, and inflammatory disease. Consequently, studies of zebrafish EPHA2A provide valuable insight into conserved receptor tyrosine kinase pathways involved in both development and disease. Because Eph receptors regulate cellular interactions rather than soluble ligand responses, they occupy a unique position among receptor tyrosine kinases and serve as key mediators of tissue patterning and homeostasis.
Zebrafish EPHA2 Antibody / Eph Receptor A2a Antibody is useful for investigations of embryonic development, receptor tyrosine kinase signaling, cell migration, angiogenesis, and tissue morphogenesis. Detection of endogenous EPHA2A provides a valuable tool for studies of developmental biology and comparative vertebrate signaling pathways.
Visit our EPHA2 Antibody page to discover additional antibodies against this Receptor Tyrosine Kinase, including reagents for studies of cell adhesion, migration, angiogenesis, and cancer signaling.
This Zebrafish antibody is part of a broader Zebrafish / Danio rerio antibody panel offered by NSJ Bioreagents.
The optimal working dilution of the Zebrafish EPHA2A Antibody should be determined empirically by the investigator.
An E.coli-derived Zebrafish EPHA2A recombinant protein (amino acids D74-A966) was used as the immunogen for the Zebrafish EPHA2A Antibody.
After reconstitution, the Zebrafish EPHA2 Antibody / Eph Receptor A2a Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Zebrafish EPHA2A Antibody, Zebrafish Ephrin Type-A Receptor 2a Antibody, Zebrafish Epithelial Cell Kinase Antibody, Zebrafish ECK Antibody, Zebrafish Receptor Tyrosine Kinase Antibody, Zebrafish Eph Receptor A2a Antibody
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