Zebrafish E-cadherin Antibody / Cdh1 / Cadherin 1 (RZ1220)

Description

E cadherin, also known as epithelial cadherin, cadherin 1 and Cdh1, is a calcium dependent cell adhesion protein that plays a key role in maintaining epithelial tissue structure and integrity. In zebrafish, E cadherin is essential for early embryonic development, particularly during processes such as epiboly, gastrulation, and organ formation.

E cadherin is a transmembrane glycoprotein that mediates homophilic cell to cell adhesion by forming adherens junctions between neighboring epithelial cells. It is a critical component of the cadherin catenin complex, which connects the actin cytoskeleton to the plasma membrane, thereby regulating tissue architecture and cell polarity.

In zebrafish embryos, E cadherin is expressed from the earliest stages of development and is especially important for coordinating cell movements and maintaining cohesion during morphogenesis. Loss or disruption of E cadherin function leads to severe defects in cell adhesion, tissue separation, and embryonic patterning.

Because of its conserved role in epithelial biology, zebrafish E cadherin is widely used in research focused on developmental biology, cancer metastasis, tissue regeneration, and epithelial to mesenchymal transition. It also serves as a valuable marker for epithelial cell identity and cell junction integrity in various model systems.

Application Notes

Optimal dilution of the Zebrafish E-cadherin antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish E-cadherin recombinant protein (amino acids Y23-D864) was used as the immunogen for the Zebrafish E-cadherin antibody.

Storage

After reconstitution, the Zebrafish E-cadherin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.