- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Zebrafish Dlx2a Antibody / Dlx2 (RZ1218)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RZ1218 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 539 |
|
| Availability | 2-3 weeks |
| Species Reactivity | Zebrafish |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity chromatography |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P50574 |
| Applications | Western Blot : 0.5-1ug/ml |
| Limitations | This Zebrafish Dlx2a antibody is available for research use only. |
|
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The Zebrafish Dlx2a antibody targets Dlx2a, a homeobox transcription factor essential for neural crest specification, craniofacial development, forebrain patterning, and early neurogenesis in Danio rerio. Zebrafish, also known as Danio rerio, express two paralogs, dlx2a and dlx2b, derived from the teleost genome duplication, with Dlx2a serving as one of the earliest markers of cranial neural crest cells and forebrain interneuron progenitors. Dlx2a encodes a nuclear protein containing a highly conserved homeodomain that binds DNA regulatory elements to control transcriptional programs guiding cell migration, differentiation, and morphogenetic patterning.
Dlx2a belongs to the Distal-less family of homeobox genes, a conserved group critical for patterning of craniofacial structures, branchial arches, and anterior brain regions. In zebrafish embryos, dlx2a expression initiates in the preplacodal region, migratory neural crest streams, and the developing telencephalon. These patterns reflect Dlx2a's role in regulating neural crest cell identity and the formation of cartilage and bone precursors within the pharyngeal skeleton. A Zebrafish Dlx2a antibody is suitable for research applications examining nuclear localization in craniofacial progenitors, neural crest migration pathways, and the formation of early forebrain neuronal lineages.
Dlx2a plays a central role in transcriptional networks that instruct cranial neural crest cells to differentiate into chondrocytes, osteoblasts, and pigment cell lineages. It interacts with other Dlx family members, including Dlx1a and Dlx5a, to coordinate gene programs that define ventral and dorsal pharyngeal arch domains. In the developing forebrain, Dlx2a contributes to the specification of GABAergic interneurons through interactions with signaling pathways such as Wnt, Shh, and Fgf. Disruptions in dlx2a expression alter craniofacial morphogenesis, branchial arch patterning, and neurogenic differentiation, underscoring its importance in integrating multiple developmental signals.
Structurally, zebrafish Dlx2a features the conserved 60 amino acid homeodomain responsible for DNA binding and transcriptional regulation. The protein localizes to the nucleus, where it interacts with chromatin regulators and co-factors that refine spatial gene expression patterns. Zebrafish dlx2a maps to chromosome 1, and its transcription is controlled by enhancer elements responsive to neural crest induction cues and forebrain regionalization signals. Co-localization studies often identify Dlx2a with markers of migrating neural crest cells such as Sox10, as well as with forebrain progenitor markers including Ascl1a and Gsx genes. These distribution patterns highlight its dual roles in both craniofacial and neural development.
A Zebrafish Dlx2a antibody is suitable for detecting Dlx2a in studies focused on neural crest biology, craniofacial patterning, forebrain development, and transcriptional regulation in Danio rerio. Its nuclear localization enables precise mapping of gene regulatory events that direct progenitor specification, tissue differentiation, and morphogenetic pattern formation. Researchers rely on Dlx2a expression to examine pharyngeal arch development, cartilage formation, neuronal lineage outcomes, and disruptions in signaling pathways affecting craniofacial or neural patterning. These features support investigations into vertebrate craniofacial biology, early neural development, and gene regulatory network integration, and this reagent is supplied for research use by NSJ Bioreagents.
Optimal dilution of the Zebrafish Dlx2a antibody should be determined by the researcher.
E. coli-derived zebrafish Dlx2a recombinant protein (amino acids D11-N261) was used as the immunogen for the Zebrafish Dlx2a antibody.
After reconstitution, the Zebrafish Dlx2a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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