- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Zebrafish Cytokeratin 8 Antibody / KRT8 Antibody recognizes Keratin 8 (KRT8), a type II intermediate filament protein that serves as a major structural component of epithelial cells. Cytokeratin 8 is one of the principal keratins expressed in simple epithelial tissues and functions together with its type I keratin partners to form intermediate filament networks that provide mechanical stability, maintain cellular architecture, and support tissue integrity. In zebrafish, KRT8 contributes to epithelial organization, tissue development, and maintenance of structural homeostasis throughout embryonic development and adulthood.
Cytokeratins are critical components of the cytoskeleton and play essential roles beyond structural support. Intermediate filament networks formed by KRT8 help regulate cell shape, intracellular organization, stress responses, and interactions with neighboring cells and the extracellular environment. These functions enable epithelial tissues to withstand mechanical stress while maintaining normal barrier and organizational properties. Because epithelial cells are fundamental to organ formation and tissue architecture, KRT8 is widely used as a marker of epithelial lineage and differentiation.
Zebrafish have become a valuable vertebrate model for studying developmental biology, tissue morphogenesis, epithelial organization, and regenerative processes. Expression of KRT8 is associated with epithelial structures undergoing growth, differentiation, and remodeling, making it a useful marker for investigations of tissue development and epithelial cell biology. The optical accessibility and genetic tractability of zebrafish further support the use of KRT8 as a tool for studying epithelial organization during vertebrate development.
Intermediate filament proteins such as KRT8 also participate in cellular responses to injury, environmental stress, and tissue remodeling. Alterations in keratin expression can influence epithelial stability, cellular signaling, and regenerative responses. Consequently, KRT8 is frequently examined in studies of epithelial differentiation, developmental regulation, tissue repair, and cytoskeletal organization. Monitoring KRT8 expression can provide valuable insight into the molecular mechanisms that govern epithelial tissue formation and maintenance.
At NSJ Bioreagents, we provide highly validated antibodies for developmental biology, epithelial biology, cytoskeletal research, and zebrafish model systems. Zebrafish Cytokeratin 8 Antibody / KRT8 Antibody is useful for investigations of epithelial development, intermediate filament biology, tissue organization, cellular architecture, regenerative processes, and cytoskeletal regulation. Continued study of KRT8 is improving our understanding of how epithelial tissues maintain structure, function, and homeostasis during development and disease.
Researchers seeking protein microarray validated detection of Keratin 8 for epithelial differentiation, cytoskeletal biology, and cancer research applications may also be interested in our Cytokeratin 8 Antibody page.
This Zebrafish antibody is part of a broader Zebrafish / Danio rerio antibody panel offered by NSJ Bioreagents.
The optimal working dilution of the Zebrafish Cytokeratin 8 Antibody / KRT8 Antibody should be determined empirically by the investigator.
An E.coli-derived Zebrafish Cytokeratin 8/KRT8 recombinant protein (amino acids S17-D520) was used as the immunogen for the Zebrafish Cytokeratin 8 Antibody.
After reconstitution, the Zebrafish Cytokeratin 8 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Zebrafish Cytokeratin 8 Antibody, Zebrafish KRT8 Antibody, Zebrafish Keratin 8 Antibody, Zebrafish Type II Cytokeratin Antibody, Zebrafish Intermediate Filament Protein Antibody, Zebrafish Epithelial Keratin Antibody
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