Zebrafish Cyp26a1 Antibody / Cytochrome P450 26A1 (RZ1216)

Description

Cyp26a1, or cytochrome P four five zero family twenty six subfamily A polypeptide one, is an enzyme that plays a central role in regulating retinoic acid levels during vertebrate development. In zebrafish, Cyp26a1 is responsible for the metabolic breakdown of retinoic acid, ensuring the proper spatial and temporal control of retinoic acid signaling.

Retinoic acid is a derivative of vitamin A that functions as a key signaling molecule in embryogenesis, influencing processes such as axis formation, organ development, and cell differentiation. Cyp26a1 expression is tightly controlled and occurs in specific patterns that help shape retinoic acid gradients across developing tissues. In zebrafish embryos, Cyp26a1 is particularly important for the formation of the head, hindbrain, and somites.

Loss of Cyp26a1 function disrupts retinoic acid homeostasis, leading to developmental abnormalities. Because of this, zebrafish Cyp26a1 is widely used as a model for studying retinoid metabolism, embryonic patterning, and the effects of vitamin A derivatives. It is also valuable in toxicological research for identifying compounds that interfere with retinoic acid signaling pathways.

Application Notes

Optimal dilution of the Zebrafish Cyp26a1 antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Cyp26a1 recombinant protein (amino acids E56-R425) was used as the immunogen for the Zebrafish Cyp26a1 antibody.

Storage

After reconstitution, the Zebrafish Cyp26a1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.