Zebrafish Cyp19a1b Antibody / Aromatase (RZ1215)

Description

Cyp19a1b, or cytochrome P four five zero family nineteen subfamily A polypeptide one b, is an aromatase enzyme that catalyzes the conversion of androgens into estrogens. In zebrafish, Cyp19a1b is the brain-specific isoform of aromatase and plays a key role in the regulation of estrogen synthesis within the central nervous system.

Cyp19a1b is predominantly expressed in radial glial cells in the zebrafish brain and is tightly regulated by estrogens and environmental factors. Its expression begins during early embryogenesis and continues throughout development and adulthood. Cyp19a1b is essential for brain development, neurogenesis, and the sexual differentiation of the brain. It also participates in the local modulation of estrogen signaling, which influences behavior, neural plasticity, and reproductive function.

Due to its strong and specific expression in the brain, zebrafish Cyp19a1b is widely used as a sensitive biomarker for estrogenic activity and for studying the effects of endocrine-disrupting chemicals. It is also an important tool for investigating the roles of neuroestrogens in development, regeneration, and brain function.

Application Notes

Optimal dilution of the Zebrafish Cyp19a1b antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Cyp19a1b recombinant protein (amino acids Q230-E511) was used as the immunogen for the Zebrafish Cyp19a1b antibody.

Storage

After reconstitution, the Zebrafish Cyp19a1b antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.