Zebrafish Androgen receptor Antibody / AR (RZ1202)

Description

Androgen receptor (AR) is a nuclear hormone receptor that functions as a ligand-activated transcription factor, mediating the biological effects of androgens such as testosterone and 11-ketotestosterone. In zebrafish (Danio rerio), AR plays a critical role in sex differentiation, reproductive organ development, and the regulation of secondary sexual characteristics.

Upon binding to its ligands, the zebrafish AR translocates to the nucleus, where it regulates the transcription of target genes involved in gonadal development, spermatogenesis, muscle growth, and behavioral traits associated with reproduction. Zebrafish express a single ar gene that is highly conserved with its mammalian counterparts and is expressed in tissues such as the gonads, brain, liver, and skin.

Zebrafish AR is widely used as a model for investigating androgen signaling pathways, endocrine disruption, and the mechanisms of sex hormone regulation in vertebrates. It is also of particular interest in toxicological studies, where it serves as a biomarker for assessing the effects of androgenic or anti-androgenic compounds in aquatic environments.

Application Notes

Optimal dilution of the Zebrafish Androgen receptor antibody should be determined by the researcher.

Immunogen

E. coli-derived zebrafish Androgen receptor recombinant protein (amino acids E12-Q852) was used as the immunogen for the Zebrafish Androgen receptor antibody.

Storage

After reconstitution, the Zebrafish Androgen receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.