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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
ZAP70 Antibody for FACS / Leukemia Lymphoma Flow Cytometry Antibody [clone 6F12] (RQ6080)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6080 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b |
| Clone Name | 6F12 |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | P43403 |
| Applications | Western Blot : 0.5-1ug/ml Flow Cytometry : 1-3ug/million cells |
| Limitations | This ZAP70 antibody is available for research use only. |
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ZAP70 antibody, also known as Zeta-chain-associated protein kinase 70 antibody, recognizes a cytoplasmic tyrosine kinase with established relevance in lymphoid malignancy research. ZAP70 Antibody for FACS is specifically designed for intracellular flow cytometry analysis of leukemia and lymphoma cell populations, enabling detailed characterization of malignant lymphocytes within complex samples. ZAP70 is expressed in T cells and subsets of B cells, and its expression patterns are frequently examined in hematologic cancer contexts.
In flow cytometry, intracellular detection of ZAP70 supports phenotyping of lymphoid malignancies by allowing researchers to evaluate protein expression within defined cancer-associated cell populations. ZAP70 expression is linked to altered signaling behavior and immune dysregulation in leukemia and lymphoma models, making it a valuable intracellular marker for studying disease-associated cellular phenotypes and signaling abnormalities.
This ZAP70 Antibody for FACS is uniquely positioned for hematologic cancer research, with a clear focus on disease-oriented flow cytometry applications rather than general immune biology. Its use enables analysis of malignant lymphocyte subsets following fixation and permeabilization, supporting investigation of tumor cell heterogeneity, signaling alterations, and immune-related disease mechanisms. This disease-centric positioning differentiates it from signaling and activation-focused ZAP70 reagents.
ZAP70 participates in signaling pathways that regulate cell survival, proliferation, and activation, and its dysregulation can contribute to aberrant lymphocyte behavior in cancer. Its detection in malignant cells provides insight into disease biology and supports studies of lymphoid neoplasia at the single-cell level. Overall, ZAP70 Antibody for FACS provides a specialized tool for flow cytometric analysis of leukemia and lymphoma samples, enabling targeted investigation of hematologic malignancies and intracellular signaling alterations in cancer research.
Optimal dilution of the ZAP70 Antibody for FACS / Leukemia Lymphoma Flow Cytometry Antibody should be determined by the researcher.
Amino acids MRKKQIDVAIKVLKQGTEKADTEEMMREAQIMHQL from the human protein were used as the immunogen for the ZAP70 Antibody for FACS / Leukemia Lymphoma Flow Cytometry Antibody.
After reconstitution, the ZAP70 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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