- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
YB1 Antibody / YBX1 / Y box binding protein 1 (R30851)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
R30851 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 429 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P67809 |
| Localization | Nuclear and cytoplasmic |
| Applications | Western blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow cytometry : 1-3ug/million cells |
| Limitations | This YB1 antibody is available for research use only. |
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Y box binding protein 1, commonly referred to as YBX1 or just YB1 by researchers, is a human protein. YBX1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414D and contains 18% basic residues and putative nuclear localization signals. The protein is highly expressed in mouse erythroid myeloid lymphoid clone-1 (EML), a hematopoietic precursor cell line, but is downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. YBX1 is expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of the protein in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant expression in leukemic cells may contribute to leukemia development by blocking differentiation.
The stated application concentrations are suggested starting amounts. Titration of the YB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the middle region of human YBX1 (KYAADRNHYRRYPRRR) was used as the immunogen for this YB1 antibody (100% homologous in human, mouse and rat).
After reconstitution, the YB1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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