- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
YAF2 Antibody recognizes YY1-associated factor 2, a widely expressed nuclear protein that functions as an important regulator of transcription, chromatin organization, and cell survival. YAF2 was originally identified through its interaction with the transcription factor Yin Yang 1 (YY1), where it can influence the recruitment of transcriptional regulatory complexes and modulate the expression of genes involved in development, differentiation, and stress responses. Beyond its association with YY1, YAF2 also serves as an adaptor protein that participates in multiple signaling pathways linking nuclear transcriptional events with broader cellular regulatory networks.
One of the best-characterized functions of YAF2 is its interaction with proteins involved in epigenetic regulation. It binds members of the Polycomb group of transcriptional repressors and contributes to chromatin-mediated gene silencing during development. These interactions help coordinate stable patterns of gene expression required for cell identity while allowing selective activation of genes in response to developmental or environmental cues. Studies have also shown that YY1-associated factor 2 participates in protein degradation pathways by interacting with ubiquitin-related regulatory proteins, further expanding its influence on transcriptional control and protein homeostasis.
YAF2 expression has been detected in numerous human tissues, with predominantly nuclear localization consistent with its transcriptional regulatory role. Increasing evidence links altered YAF2 activity to cancer biology, apoptosis, and cellular stress responses. Depending on the cellular context, YAF2 may either promote or suppress apoptosis through interactions with signaling proteins and transcriptional regulators. Additional research has implicated the protein in embryonic development, neuronal function, and differentiation, making it relevant across a broad range of developmental and disease-focused investigations. Because it integrates chromatin regulation with transcription factor activity, YAF2 continues to attract interest in studies of epigenetics and gene expression.
An YAF2 Antibody is a valuable research tool for detecting endogenous YAF2 expression, examining YY1-associated factor 2 localization, and investigating mechanisms of transcriptional regulation, chromatin remodeling, apoptosis, and developmental biology.
Explore our Transcription Factor Antibodies page to discover additional antibodies for studying transcriptional regulation, gene expression, and nuclear signaling pathways.
Optimal dilution of the YAF2 Antibody / YY1-associated factor 2 Antibody should be determined by the researcher.
E.coli-derived human YY1-associated factor 2 recombinant protein (amino acids R51-H180) was used as the immunogen for the YAF2 Antibody.
After reconstitution, the YAF2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
YAF2 antibody, YY1-associated factor 2 antibody
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