- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
XRCC5 Antibody / Nuclear Localization and Redistribution Antibody [clone XRCC5/7315] (V8929)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8929-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
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V8929-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V8929SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | XRCC5/7315 |
| Purity | Protein A/G affinity |
| UniProt | P13010 |
| Localization | Nucleus |
| Applications | Western Blot : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This XRCC5/Ku80 antibody is available for research use only. |
|
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XRCC5 (Ku80) is a nuclear DNA repair protein that exhibits dynamic subcellular localization, making it an important marker for studying protein distribution within cells. XRCC5 Antibody is uniquely positioned for investigations focused on nuclear localization and intracellular redistribution, where spatial positioning of proteins provides insight into functional state and cellular response to environmental conditions. Under basal conditions, XRCC5 is predominantly localized to the nucleus, where it participates in DNA repair through interaction with chromatin and DNA break sites.
XRCC5 Antibody is uniquely positioned for examining changes in protein localization that occur in response to cellular stress, DNA damage, or alterations in nuclear transport mechanisms. XRCC5 antibody, also known as Ku80 antibody, detects a protein that can display both nuclear and cytoplasmic staining depending on cell type, fixation conditions, and biological context. This dual localization reflects the presence of both chromatin-bound and unbound protein pools, as well as dynamic movement between cellular compartments.
In imaging-based studies, XRCC5 localization patterns can change in response to genotoxic stress, with increased nuclear accumulation or redistribution into subnuclear regions associated with DNA repair activity. Cytoplasmic signal may also be observed, representing newly synthesized protein, protein in transit, or non-engaged pools that are not bound to DNA. These patterns provide valuable information about protein mobility, functional engagement, and the dynamic regulation of DNA repair proteins within the cell.
XRCC5 is widely expressed across tissues and plays a central role in maintaining genomic stability, but its localization is not static. Changes in localization can reflect activation of repair pathways, alterations in chromatin organization, or shifts in cellular state such as proliferation or stress response. This makes XRCC5 particularly useful for studies that rely on spatial interpretation of protein behavior rather than simple measurement of expression levels.
As a member of the DNA repair protein family, XRCC5 functions primarily within the nucleus but retains the capacity for dynamic redistribution in response to changing cellular conditions. XRCC5 Antibody provides a valuable tool for researchers examining subcellular localization, protein trafficking, and spatial regulation of DNA repair processes. Its ability to reveal both nuclear enrichment and cytoplasmic distribution makes it especially useful for studies focused on protein localization and intracellular dynamics.
Optimal dilution of the XRCC5 Antibody / Nuclear Localization and Redistribution Antibody should be determined by the researcher.
A portion of amino acids 300-500 was used as the immunogen for the XRCC5 Antibody / Nuclear Localization and Redistribution Antibody.
Aliquot the XRCC5/Ku80 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Ku80 antibody, XRCC5 localization antibody, Ku80 nuclear cytoplasmic antibody, XRCC5 redistribution antibody, Ku80 trafficking antibody
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