- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
XRCC5 Antibody / Genotoxic Stress Response Antibody [clone XRCC5/7312] (V4943)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4943-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4943-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4943SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2c, kappa |
| Clone Name | XRCC5/7312 |
| Purity | Protein A/G affinity |
| UniProt | P13010 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This XRCC5 antibody is available for research use only. |
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XRCC5 (Ku80) is a DNA repair protein that plays a central role in cellular responses to genotoxic stress, where detection and repair of DNA damage are essential for maintaining cell viability and genomic integrity. XRCC5 Antibody is uniquely positioned for studies focused on genotoxic stress response, enabling analysis of how cells detect and respond to DNA damage caused by radiation, oxidative stress, and chemical agents. As part of the Ku heterodimer with XRCC6, XRCC5 binds DNA double-strand breaks and initiates repair processes that are critical for survival under stress conditions.
XRCC5 Antibody is uniquely positioned for investigating the cellular response to DNA damage, where rapid activation of repair pathways determines whether cells recover or undergo cell death. XRCC5 antibody, also referred to as Ku80 antibody, detects a nuclear protein that is rapidly recruited to sites of DNA damage following genotoxic insult. This rapid response makes XRCC5 a key marker for studying early events in the DNA damage response and assessing how cells react to environmental and endogenous stressors.
Under conditions of genotoxic stress, XRCC5 activity increases as cells attempt to repair DNA lesions and restore genomic stability. The extent and efficiency of this response can vary depending on the severity of damage and the cellular context, providing valuable information about cellular resilience and repair capacity. Detection of XRCC5 allows researchers to monitor activation of repair pathways and to evaluate how effectively cells respond to DNA-damaging conditions.
XRCC5 is particularly relevant in cancer research, where tumor cells often rely on enhanced DNA repair mechanisms to survive therapeutic interventions. Its involvement in stress response pathways makes it a useful marker for evaluating sensitivity to radiation and DNA-damaging chemotherapeutic agents. Changes in XRCC5 expression or localization can reflect alterations in repair capacity and cellular adaptation to stress.
As a member of the DNA repair protein family, XRCC5 integrates DNA damage detection with activation of repair processes that determine cellular outcomes. Its role in genotoxic stress response provides a distinct functional identity that is closely tied to cellular survival mechanisms. XRCC5 Antibody provides a focused tool for analyzing DNA damage response activation, cellular stress adaptation, and the mechanisms that preserve genomic integrity under adverse conditions.
Optimal dilution of the XRCC5 Antibody / Genotoxic Stress Response Antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the XRCC5 Antibody / Genotoxic Stress Response Antibody.
Aliquot the XRCC5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Ku80 antibody, XRCC5 stress response antibody, Ku80 genotoxic stress antibody, XRCC5 DNA damage response antibody, Ku80 repair stress marker antibody
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