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Home >> Antibodies >> XIAP Antibody / IAP3

XIAP Antibody / IAP3 (R32372)

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  Catalog No Formulation Size Price (USD)  
Image R32372 0.5mg/ml if reconstituted with 0.2ml sterile DI water 100 ug 429
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Western blot testing of human 1) HeLa and 2) 293T cell lysate with XIAP antibody. Expected molecular weight ~57 kDa.
Western blot testing of human 1) HeLa and 2) 293T cell lysate with XIAP antibody. Expected molecular weight ~57 kDa.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit IgG
Purity Antigen affinity
Buffer Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
UniProt P98170
Applications Western blot : 0.5-1ug/ml
Limitations This XIAP antibody is available for research use only.
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Description

XIAP, also known as IAP3 or BIRC4, is a protein that stops apoptotic cell death. It is mapped to chromosome Xq25. This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants.

Application Notes

Optimal dilution of the XIAP antibody should be determined by the researcher.

Immunogen

Amino acids A15-V244 were used as the immunogen for the XIAP antibody.

Storage

After reconstitution, the XIAP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

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