- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
vWF Antibody / Vascular Permeability Marker Antibody [clone VWF/2480] (V8164)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8164-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8164-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8164SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | VWF/2480 |
| Purity | Protein G affinity chromatography |
| UniProt | P04275 |
| Localization | Cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This vWF antibody is available for research use only. |
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Von Willebrand factor (VWF) is a secreted glycoprotein encoded by the VWF gene and synthesized primarily by vascular endothelial cells and megakaryocytes. vWF Antibody / Vascular Permeability Marker Antibody recognizes a protein that is closely associated with endothelial cells and their functional role in maintaining vascular barrier integrity. VWF antibody, also referred to as von Willebrand factor antibody or factor VIII-related antigen antibody, is widely used in studies examining endothelial barrier function, vascular leakage, and permeability-related changes in tissue.
Endothelial cells form a selective barrier that regulates the movement of fluids, proteins, and cells between the bloodstream and surrounding tissue. Disruption of this barrier can result in increased vascular permeability, leading to edema, inflammatory infiltration, and altered tissue homeostasis. Because VWF is synthesized and stored within endothelial cells and released during activation, its presence and distribution can reflect changes in endothelial state associated with barrier dysfunction.
In conditions where vascular permeability is increased, endothelial cells often undergo structural and functional changes, including junctional disruption, cytoskeletal rearrangement, and altered secretion of mediators. VWF release is frequently associated with these activation states, linking endothelial response to changes in vascular barrier properties. Detection of VWF can therefore provide insight into regions where endothelial cells are responding to stimuli that impact permeability.
Within tissue sections, VWF staining highlights endothelial-lined vessels and can reveal areas where vascular organization or signal intensity differs across regions. In permeability-related studies, these differences may correspond to localized endothelial activation or altered barrier function. The ability to visualize vascular structures alongside changes in VWF-associated signal supports interpretation of how vascular compartments respond to physiological or pathological conditions.
Vascular permeability plays a central role in inflammation, tumor biology, ischemia, and tissue injury. Increased permeability can facilitate immune cell trafficking, nutrient exchange, and, in some contexts, pathological leakage that contributes to disease progression. Because endothelial cells are the primary regulators of this barrier, markers that reflect endothelial presence and activation are valuable tools for studying these processes. VWF provides a biologically relevant readout that connects endothelial identity with functional vascular response.
vWF Antibody / Vascular Permeability Marker Antibody is especially suited for studies focused on endothelial barrier function and vascular leakage. By highlighting endothelial-lined structures and providing insight into activation-associated changes, it supports investigation of permeability dynamics, vascular response to injury, and the regulation of barrier integrity across a wide range of biological systems.
Optimal dilution of the vWF Antibody / Vascular Permeability Marker Antibody should be determined by the researcher.
A recombinant full-length human protein was used as the immunogen for this vWF Antibody / Vascular Permeability Marker Antibody.
Store the vWF antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
VWF vascular permeability antibody, vWF endothelial barrier marker antibody, vascular leakage marker antibody, VWF vessel permeability antibody, endothelial barrier function antibody
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