von Willebrand Factor Antibody / Weibel-Palade Body Marker Antibody [clone VWF/4106] (V8821)

von Willebrand Factor Antibody / Weibel-Palade Body Marker Antibody. Immunohistochemistry analysis of human tonsil tissue shows HRP-DAB brown staining of endothelial cells lining vascular channels, with intracellular signal reflecting VWF localization within Weibel-Palade bodies. The staining appears as granular and focal cytoplasmic deposition along vessel linings, consistent with endothelial storage organelles within these cells. This pattern highlights both vascular structures and the subcellular distribution of VWF within endothelial compartments. Clone VWF/4106 enables visualization of vessel-associated endothelium with organelle-level detail. Negative control inset shows absence of staining when PBS is used instead of primary antibody, confirming specificity of the detected signal. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

von Willebrand Factor Antibody / Weibel-Palade Body Marker Antibody. Immunohistochemistry analysis of human pancreatic tissue shows HRP-DAB brown staining of endothelial cells lining vascular channels, with signal localized to the cytoplasm in a granular pattern consistent with VWF-containing Weibel-Palade bodies. The staining outlines elongated vessel structures within the pancreatic stroma, while intracellular deposition highlights endothelial storage organelles along the vessel lining. Clone VWF/4106 enables visualization of both vascular architecture and subcellular VWF localization within endothelial compartments. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

SDS-PAGE analysis of purified, BSA-free von Willebrand Factor antibody (VWF/4106) as confirmation of integrity and purity.

Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using von Willebrand Factor antibody (clone VWF/4106). These results demonstrate the foremost specificity of the VWF/4106 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt(TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt(TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.