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- Tel: 858.663.9055
- Email: info@nsjbio.com
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Von Willebrand Factor is a blood glycoprotein involved in hemostasis. The VWF gene encodes a large multimeric glycoprotein that plays a central role in the blood coagulation system, serving both as a major mediator of platelet-vessel wall interaction and platelet adhesion, and as a carrier for coagulation factor VIII. vWF released from endothelial cell Weibel-Palade bodies bound particularly avidly to the extracellular matrix. Deficiency or dysfunction (von Willebrand disease) leads to a bleeding tendency, which is most apparent in tissues having high blood flow shear in narrow vessels.
Variations in secondary/substrate sensitivities and test protocols may require the von Willebrand Factor antibody to be titrated for optimal performance.
Mouse partial recombinant protein (AA 1304-1452) was used as the immunogen for this von Willebrand Factor antibody.
The von Willebrand Factor antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freeze/thaws.
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