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Home >> Antibodies >> VLDLR Antibody / VLDL Receptor

VLDLR Antibody / VLDL Receptor [clone rVLDLR/1337] (V9635)

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  Catalog No Formulation Size Price (USD)  
Image V9635-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 100 ug 519
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V9635-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide 20 ug 229
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V9635SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
Microvalidated Recmousemono
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IHC staining of FFPE human pancreatic tissue with VLDLR antibody (clone rVLDLR/1337). Negative control inset: PBS instead of primary antibody to control for secondary binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
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IHC staining of FFPE human pancreatic tissue with VLDLR antibody (clone rVLDLR/1337). Negative control inset: PBS instead of primary antibody to control for secondary binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
SDS-PAGE analysis of purified, BSA-free VLDLR antibody (clone rVLDLR/1337) as confirmation of integrity and purity.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Recombinant Mouse Monoclonal
Isotype Mouse IgG1, kappa
Clone Name rVLDLR/1337
Purity Protein A/G affinity
UniProt P98155
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 1-2ug/ml
Limitations This VLDLR antibody is available for research use only.
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Description

VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development.

Application Notes

Optimal dilution of the VLDLR antibody should be determined by the researcher.

Immunogen

A recombinant human protein fragment from the C-terminal region was used as the immunogen for the VLDLR antibody.

Storage

Aliquot the VLDLR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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