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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Villin Antibody / Epithelial Tumor Marker Antibody [clone VIL1/1325] (V3369)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V3369-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V3369-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V3369SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | VIL1/1325 |
| Purity | Protein G affinity chromatography |
| Buffer | 1X PBS, pH 7.4 |
| UniProt | P09327 |
| Localization | Cytoplasmic and cell surface |
| Applications | Western Blot : 1-2ug/ml for 60 min at RT Immunohistochemistry (FFPE) : 0.25-0.5ug/ml for 30 min at RT |
| Limitations | This Villin antibody is available for research use only. |
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Villin-1 (VIL1) is an actin-binding cytoskeletal protein that is widely expressed in gastrointestinal epithelium and is frequently retained in epithelial tumors of intestinal origin, making it a valuable marker in cancer biology. Villin Antibody / Epithelial Tumor Marker Antibody (clone VIL1/1325) is designed to detect this tumor-associated protein, and Villin antibody, also known as Villin-1 antibody or VIL1 antibody, is commonly used in studies of colorectal cancer, gastrointestinal tumors, and epithelial malignancies. As an epithelial tumor marker, Villin is particularly useful for identifying tumor cells derived from intestinal epithelium and for supporting tumor classification based on lineage.
In colorectal cancer and related gastrointestinal adenocarcinomas, Villin expression is often preserved in tumor epithelial cells, reflecting their origin from differentiated intestinal tissue. Researchers using a Villin Antibody / Epithelial Tumor Marker Antibody are typically focused on detecting malignant epithelial cells, confirming gastrointestinal tumor origin, and distinguishing adenocarcinomas from non-epithelial or non-GI tumors. This cancer-focused positioning clearly separates this antibody from other Villin pages that emphasize normal epithelial structure, polarity, or cytoskeletal function.
Villin expression patterns in tumors can provide insight into tumor differentiation and organization. Well-differentiated colorectal tumors often show strong, organized Villin expression associated with glandular structures, while poorly differentiated tumors may exhibit reduced or heterogeneous staining. These differences make Villin a useful marker for evaluating tumor differentiation status and for identifying epithelial tumor components within complex tissue samples. Villin Antibody / Epithelial Tumor Marker Antibody is therefore particularly valuable in studies where tumor identification, classification, and differentiation are primary objectives.
This mouse monoclonal antibody (clone VIL1/1325) provides specific recognition of Villin as an epithelial tumor marker, supporting reliable detection of tumor-associated epithelial cells in colorectal cancer and other gastrointestinal malignancies. It is well suited for research focused on tumor classification, epithelial lineage identification, and cancer biology, where accurate detection of gastrointestinal tumor markers is essential.
The stated application concentrations are suggested starting points. Titration of the Villin Antibody / Epithelial Tumor Marker Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 179-311 from the human protein were used as the immunogen for this Villin Antibody / Epithelial Tumor Marker Antibody.
Store the Villin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Villin-1 antibody, VIL1 antibody, Villin 1 antibody, Villin antibody
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