- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Villin Antibody / Cytoskeletal Remodeling Protein Antibody [clone AFOA-22] (RQ5271)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5271 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AFOA-22 |
| Purity | Affinity purified |
| UniProt | P09327 |
| Applications | Western Blot : 1:1000-1:5000 |
| Limitations | This Villin antibody is available for research use only. |
|
Review this product on BioCompare and get a $20 Amazon gift card
|
Related Products
|
Villin-1 (VIL1) is a calcium-sensitive actin regulatory protein that functions as a rapid-response mediator of cytoskeletal remodeling in epithelial cells. Villin Antibody / Cytoskeletal Remodeling Protein Antibody (clone AFOA-22) is specifically positioned to detect Villin in contexts where actin filament dynamics, rather than static structure, are the primary biological focus. Villin antibody, also known as Villin-1 antibody or VIL1 antibody, is therefore highly relevant in studies examining cytoskeletal turnover, epithelial stress responses, and injury-driven remodeling processes.
Unlike Villin antibodies framed around brush border architecture or epithelial identity, this Villin Antibody / Cytoskeletal Remodeling Protein Antibody is differentiated by its emphasis on dynamic actin regulation. Villin is a member of the gelsolin superfamily and can rapidly switch between actin-severing, capping, and nucleating functions depending on intracellular calcium levels. These reversible activities allow Villin to actively dismantle and rebuild actin filaments, making it a central regulator of cytoskeletal plasticity rather than a purely structural component of microvilli.
Functionally, Villin plays a key role during epithelial injury, regeneration, and high-turnover states, where cytoskeletal reorganization is required for cell survival and adaptation. Under conditions such as mechanical stress, inflammation, or tissue damage, Villin-mediated actin remodeling contributes to changes in membrane dynamics, cell shape, and epithelial restitution. This positions Villin as an important molecular marker for studies focused on epithelial repair mechanisms, cytoskeletal turnover, and adaptive remodeling rather than baseline tissue architecture.
From a research perspective, this Villin antibody is particularly useful for investigators studying actin remodeling pathways, injury-induced cytoskeletal changes, and epithelial turnover biology, where Villin activity reflects ongoing structural reorganization. Clone AFOA-22 supports detection of Villin in these dynamic biological contexts, providing a tool aligned with mechanistic cell biology applications rather than purely histological or differentiation-based analyses.
Optimal dilution of the Villin Antibody / Cytoskeletal Remodeling Protein Antibody should be determined by the researcher.
A synthetic peptide specific to human Villin / VIL1 was used as the immunogen for the Villin Antibody / Cytoskeletal Remodeling Protein Antibody.
Store the Villin antibody at -20oC.
Villin-1 antibody, VIL1 antibody, Villin actin remodeling antibody, Villin cytoskeleton regulator antibody
Your bulk quote request has been submitted successfully!
Please contact us if you have any questions.
Powered by Bioz
