- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Villin Antibody / Intestinal Differentiation Marker Antibody [clone VIL1/1314 + VIL1/2376] (V8156)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8156-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
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V8156-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8156SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa + Mouse IgG1, kappa |
| Clone Name | VIL1/1314 + VIL1/2376 |
| Purity | Protein G affinity chromatography |
| UniProt | P09327 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Villin antibody cocktail is available for research use only. |
|
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Villin-1 (VIL1) is an actin-binding cytoskeletal protein that serves as a well-established marker of intestinal epithelial differentiation, with expression tightly linked to mature enterocytes and functional epithelial maturation. Villin Antibody / Intestinal Differentiation Marker Antibody (clones VIL1/1314 + VIL1/2376) is designed to detect this differentiation-associated protein, and Villin antibody, also known as Villin-1 antibody or VIL1 antibody, is widely used to assess enterocyte lineage and differentiation state within the gastrointestinal epithelium. As an intestinal differentiation marker, Villin expression is minimal in undifferentiated progenitor cells and becomes strongly upregulated as cells acquire mature absorptive characteristics.
The transition from intestinal stem or progenitor cells to fully differentiated enterocytes is accompanied by increased Villin expression, making it a reliable indicator of epithelial maturation status. Researchers using a Villin Antibody / Intestinal Differentiation Marker Antibody are typically focused on distinguishing differentiated enterocytes from less differentiated or dedifferentiated cell populations. This is particularly important in studies of intestinal development, epithelial regeneration, and cancer, where loss of differentiation is a defining feature of tumor progression. The use of dual mouse monoclonal clones VIL1/1314 and VIL1/2376 enhances detection across samples with varying expression levels, supporting consistent identification of differentiation status.
In normal intestinal tissue, Villin expression is strongly associated with mature enterocytes lining the luminal surface, reflecting a fully differentiated epithelial state. In contrast, reduced or heterogeneous Villin expression is often observed in poorly differentiated tumors or regenerating epithelium, where cells have not fully acquired enterocyte identity. This makes Villin a valuable marker for assessing epithelial differentiation gradients, identifying lineage commitment, and evaluating the extent of dedifferentiation in pathological samples. Villin Antibody / Intestinal Differentiation Marker Antibody is therefore particularly useful in studies where differentiation state, rather than simple epithelial presence, is the primary biological question.
This dual-clone mouse monoclonal antibody combination (VIL1/1314 + VIL1/2376) provides robust and consistent recognition of Villin as an intestinal differentiation marker, supporting reliable detection of enterocyte maturation across a range of epithelial samples. It is well suited for research focused on intestinal lineage specification, epithelial maturation, and differentiation state, where precise identification of differentiated versus undifferentiated epithelial cells is essential.
Optimal dilution of the Villin Antibody / Intestinal Differentiation Marker Antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 179-311) was used as the immunogen for this Villin Antibody / Intestinal Differentiation Marker Antibody.
Store the Villin antibody cocktail at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Villin-1 antibody, VIL1 antibody, Villin 1 antibody, Villin antibody
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