- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
VIL1 Antibody / Calcium-Regulated Actin Protein Antibody [clone AFGO-22] (RQ5272)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ5272 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ul | 449 |
|
| Availability | 1-2 weeks |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | AFGO-22 |
| Purity | Affinity purified |
| UniProt | P09327 |
| Applications | Western Blot : 1:1000-1:10000 |
| Limitations | This VIL1 antibody is available for research use only. |
|
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Villin-1 (VIL1) is a calcium-dependent actin-binding protein that functions as a molecular switch controlling actin filament organization in epithelial cells. VIL1 Antibody / Calcium-Regulated Actin Protein Antibody is designed to detect Villin in contexts where calcium signaling governs cytoskeletal behavior. VIL1 antibody, also known as Villin-1 antibody or Villin antibody, is particularly relevant in studies examining calcium-driven actin remodeling and signal-dependent cytoskeletal responses.
What differentiates this VIL1 Antibody / Calcium-Regulated Actin Protein Antibody from other Villin-focused pages is its emphasis on calcium-regulated functional switching. Villin belongs to the gelsolin family and exhibits distinct activities depending on intracellular calcium levels, including actin severing at high calcium concentrations and filament stabilization or bundling at lower levels. This calcium sensitivity allows Villin to function as a key mediator linking signaling pathways to structural cytoskeletal outcomes.
In epithelial cells, fluctuations in calcium signaling are closely tied to processes such as secretion, membrane trafficking, and barrier regulation. Villin participates in these processes by modulating actin architecture in response to signaling cues, enabling rapid structural adaptation. This makes it a useful marker for studying how intracellular signaling pathways influence cytoskeletal organization at a mechanistic level.
From a research standpoint, this VIL1 antibody is especially suited for investigations into calcium-dependent cytoskeletal regulation, signaling-driven actin dynamics, and epithelial response to intracellular signaling events. VIL1 Antibody / Calcium-Regulated Actin Protein Antibody supports detection of Villin in these signaling-focused contexts, differentiating it from antibodies positioned around morphology or tissue identity.
Optimal dilution of the VIL1 Antibody / Calcium-Regulated Actin Protein Antibody should be determined by the researcher.
A synthetic peptide specific to human Villin / VIL1 was used as the immunogen for the VIL1 Antibody / Calcium-Regulated Actin Protein Antibody.
Store the VIL1 antibody at -20oC.
Villin-1 antibody, Villin calcium-regulated protein antibody, VIL1 actin regulator antibody, Villin calcium signaling antibody
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