VHL Antibody Biotin Conjugate (R35773BTN)

Description

VHL Antibody Biotin Conjugate is designed for the detection and study of VHL (Von Hippel-Lindau protein), a highly conserved regulator of cellular oxygen-sensing pathways and hypoxia-responsive signaling networks. VHL functions as a component of an E3 ubiquitin ligase complex that controls the stability of hypoxia-inducible factor (HIF) proteins, thereby helping coordinate cellular responses to oxygen availability. Through this activity, VHL serves as a central mediator of hypoxia signaling, angiogenesis, metabolic adaptation, and maintenance of cellular homeostasis.

VHL plays an essential role in regulating pathways that influence cellular growth, survival, differentiation, and adaptation to environmental stress. Under normal oxygen conditions, VHL promotes degradation of HIF proteins and prevents inappropriate activation of hypoxia-responsive genes. Reduced oxygen availability allows HIF accumulation and activation of transcriptional programs involved in vascular development, energy metabolism, and cellular adaptation. This tightly controlled process is critical for maintaining physiologic oxygen balance within tissues.

As one of the best-characterized tumor suppressor proteins, VHL has been extensively studied in cancer biology, vascular biology, developmental biology, and hypoxia research. In addition to regulating HIF-dependent pathways, VHL participates in broader cellular processes including protein turnover, extracellular matrix regulation, and maintenance of normal tissue architecture. These diverse functions have established VHL as an important research target for understanding how cells sense and respond to changing environmental conditions.

VHL Antibody Biotin Conjugate is useful for evaluating VHL expression and investigating molecular pathways involved in hypoxia signaling, oxygen sensing, angiogenesis, metabolism, and cellular homeostasis. The biotin conjugate format enables sensitive detection strategies in a variety of research applications utilizing biotin-streptavidin-based visualization and assay systems.

For additional information on VHL function, hypoxia signaling pathways, and oxygen-sensing mechanisms, visit our VHL Antibody / Tumor Suppressor Protein Antibody page.

Application Notes

Optimal dilution of the VHL antibody should be determined by the researcher.

1. Isoforms 1 (213 AA) and 2 (172 AA) may be detected with this Ab.

Immunogen

Amino acids RSLVKPENYRRLD were used as the immunogen for this VHL antibody.

Storage

Aliquot and store the VHL antibody at -20oC.