- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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VGLUT1 Antibody / Vesicular Glutamate Transporter 1 Antibody recognizes Vesicular Glutamate Transporter 1 (VGLUT1), the protein encoded by the SLC17A7 gene and a principal mediator of glutamate packaging into synaptic vesicles. VGLUT1 is highly enriched in excitatory neurons of the central nervous system, where it concentrates glutamate within synaptic vesicles before calcium-dependent neurotransmitter release. This vesicular transport process is essential for efficient excitatory synaptic transmission, neuronal communication and higher brain function. NSJ Bioreagents provides VGLUT1 antibodies for investigations of synaptic physiology, neuronal connectivity and glutamatergic signaling.
VGLUT1 is expressed predominantly in the cerebral cortex, hippocampus, cerebellum and other glutamatergic brain regions. Localized to presynaptic vesicle membranes, the transporter utilizes the proton electrochemical gradient generated by vesicular proton pumps to accumulate glutamate inside synaptic vesicles. Because of its selective neuronal expression, VGLUT1 is widely used as a marker of glutamatergic presynaptic terminals and excitatory neuronal populations in both normal and diseased nervous tissue. Analysis of VGLUT1 expression provides valuable insight into synaptic organization, neuronal circuitry and neurotransmitter release mechanisms.
Altered VGLUT1 expression has been associated with epilepsy, Alzheimer's disease, Parkinson's disease, schizophrenia, autism spectrum disorders and other neurological conditions characterized by disrupted glutamatergic neurotransmission. Changes in VGLUT1 abundance may influence synaptic plasticity, learning, memory and excitotoxicity, making the transporter an important biomarker and research target in neuroscience. Studies of VGLUT1 continue to improve understanding of synaptic dysfunction and the molecular basis of neurological disease.
A VGLUT1 Antibody is a valuable reagent for detecting Vesicular Glutamate Transporter 1 by Western blotting, immunohistochemistry, immunofluorescence, immunoprecipitation and related immunoassays. A Vesicular Glutamate Transporter 1 Antibody supports investigations of excitatory synapses, glutamatergic neurons, synaptic vesicle biology and neurotransmitter release.
For an overview of SLC17A7 function and glutamatergic neurotransmission, visit our SLC17A7 Antibody / Glutamate Transporter Antibody page.
Optimal dilution of the VGLUT1 Antibody / Vesicular Glutamate Transporter 1 Antibody should be determined by the researcher.
Amino acids HDQLAGSDDSEMED were used as the immunogen for this VGLUT1 antibody.
Aliquot and store the VGLUT1 antibody at -20oC.
VGLUT1 antibody, Vesicular Glutamate Transporter 1 antibody, SLC17A7 antibody, BNPI antibody
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