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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
VEGFR2 Antibody DC101 / CD309 Antibody [clone DC101] (V8272)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V8272-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
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V8272-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
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V8272SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Mouse |
| Format | Purified |
| Host | Rat |
| Clonality | Monoclonal (rat origin) |
| Isotype | Rat IgG1, kappa |
| Clone Name | DC101 |
| Purity | Protein G affinity chromatography |
| UniProt | P35918 |
| Applications | Western Blot (Non-reducing) : 2-5ug/ml |
| Limitations | This VEGFR2 Antibody DC101 / CD309 Antibody is available for research use only. |
|
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VEGFR2 Antibody DC101 / CD309 Antibody recognizes vascular endothelial growth factor receptor 2, a receptor tyrosine kinase that plays a central role in VEGF-dependent angiogenesis and vascular biology. VEGFR2 is also designated CD309 and is encoded by KDR in humans, while the corresponding mouse receptor is commonly called Flk1. VEGFR2 functions as a major signaling receptor through which VEGF regulates endothelial cell proliferation, migration, survival and vascular permeability.
VEGFR2 contains an extracellular ligand-binding region, a single transmembrane segment and an intracellular split tyrosine kinase domain. VEGF binding promotes receptor dimerization and kinase activation, followed by phosphorylation of intracellular tyrosine residues. These events recruit signaling proteins and activate pathways including phospholipase C gamma, MAPK/ERK and PI3K/AKT, linking extracellular VEGF signals to changes in endothelial cell behavior.
CD309 signaling is essential for formation and remodeling of the vascular system. VEGFR2-mediated responses contribute to endothelial proliferation and migration during new blood vessel formation and also influence vessel permeability and survival. These functions make the receptor important in developmental angiogenesis as well as vascular responses occurring in adult tissues.
The VEGF-VEGFR2 axis is extensively investigated in cancer because formation of tumor-associated vasculature can support tumor growth and progression. VEGFR2 has consequently become an important experimental target in studies of angiogenesis and anti-angiogenic strategies. Clone DC101 has an established research history as an antibody directed against mouse VEGFR2 and has been used in published experimental studies investigating blockade of VEGF receptor signaling and tumor-associated angiogenesis.
NSJ Bioreagents offers clone DC101 as a monoclonal reagent for research into VEGFR2 biology, VEGF signaling and angiogenesis. The VEGFR2 Antibody terminology identifies the widely recognized receptor name, while CD309 Antibody provides its established cluster-of-differentiation designation.
A VEGFR2 Antibody provides a monoclonal reagent for investigating VEGF receptor biology and angiogenic signaling, while a CD309 Antibody provides an alternative established designation for research involving this vascular receptor.
For another antibody targeting the same receptor, see our VEGFR2 Antibody / KDR Polyclonal Antibody.
Optimal dilution of the VEGFR2 Antibody DC101 / CD309 Antibody should be determined by the researcher.
Recombinant full-length Mouse VEGFR2 protein was used as the immunogen for this VEGFR2 Antibody DC101.
Store the VEGFR2 Antibody DC101 at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
CD309 antibody, KDR antibody, VEGF Receptor 2 antibody, Vascular Endothelial Growth Factor Receptor 2 antibody, Flk1 antibody
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