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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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VEGFR2 Antibody / KDR Polyclonal Antibody recognizes vascular endothelial growth factor receptor 2, a receptor tyrosine kinase encoded by the KDR gene. VEGFR2 is a major signaling receptor for vascular endothelial growth factors and plays a central role in angiogenesis, vascular development and endothelial cell biology. The receptor is also known as KDR and CD309, while Flk1 is widely used for the corresponding mouse receptor.
VEGFR2 is a single-pass transmembrane protein containing an extracellular ligand-binding region, a transmembrane segment and an intracellular tyrosine kinase domain. Binding of VEGF promotes receptor dimerization and tyrosine phosphorylation, creating docking sites for signaling proteins that transmit VEGF-dependent signals into the cell. VEGF-A is the principal ligand associated with VEGFR2 activation, although additional VEGF family members can engage the receptor.
Signaling through KDR regulates endothelial cell proliferation, migration, survival and vascular permeability. Major downstream pathways include the MAPK/ERK, PI3K/AKT and phospholipase C gamma signaling cascades. Together, these pathways allow endothelial cells to respond to pro-angiogenic signals and contribute to the formation, remodeling and maintenance of blood vessels. VEGFR2 therefore occupies a central position in the molecular regulation of physiological and pathological angiogenesis.
VEGFR2 is extensively studied in cancer because tumor growth and metastatic progression can depend on development of an adequate blood supply. Increased VEGF signaling can promote tumor-associated angiogenesis, making the VEGF-VEGFR2 axis an important area of oncology and therapeutic research. KDR signaling is also relevant to developmental vascular biology, wound repair, inflammation and disorders involving abnormal vascular growth or permeability.
NSJ Bioreagents offers this VEGFR2 Antibody for research into VEGF signaling, receptor tyrosine kinase biology and angiogenesis. The KDR Polyclonal Antibody terminology provides the corresponding gene-based designation and distinguishes VEGFR2 from other members of the VEGF receptor family.
A VEGFR2 Antibody provides a polyclonal reagent for investigating vascular endothelial growth factor receptor 2 expression and signaling, while a KDR Polyclonal Antibody supports studies of angiogenesis, endothelial biology and VEGF-dependent pathways.
Explore additional antibodies involved in receptor signaling and intracellular regulatory pathways on our Signal Transduction Antibodies page.
Optimal dilution of the VEGFR2 Antibody / KDR Polyclonal Antibody should be determined by the researcher.
A recombinant human protein corresponding to amino acids A20-L242 was used as the immunogen for the VEGFR2 Antibody.
After reconstitution, the VEGFR2 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
KDR antibody, VEGF Receptor 2 antibody, Vascular Endothelial Growth Factor Receptor 2 antibody, CD309 antibody, Kinase Insert Domain Receptor antibody
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