- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
VEGFD Antibody / VEGF-D Polyclonal Antibody (R31821)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R31821 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide |
| UniProt | O43915 |
| Localization | Cytoplasmic, secreted |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml |
| Limitations | This VEGFD Antibody / VEGF-D Polyclonal Antibody is available for research use only. |
|
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VEGFD Antibody recognizes vascular endothelial growth factor D (VEGF-D), a secreted signaling protein encoded by the VEGFD gene, also known as FIGF. VEGF-D belongs to the vascular endothelial growth factor family, which regulates the development, maintenance, and remodeling of blood and lymphatic vessels. Originally identified as a c-fos-induced growth factor, VEGF-D is particularly important for lymphangiogenesis, the formation and expansion of lymphatic vessels. Its biological activity is mediated primarily through interactions with VEGFR-3 (FLT4) and VEGFR-2 (KDR), receptor tyrosine kinases that coordinate vascular growth and endothelial cell responses.
The human VEGFD gene is located on chromosome Xp22.31 and encodes a precursor protein of approximately 354 amino acids. VEGF-D is synthesized as a secreted glycoprotein containing an N-terminal propeptide, a central VEGF homology domain, and a C-terminal propeptide. Proteolytic processing removes the terminal regions and generates mature VEGF-D with increased receptor-binding activity. Different processing states influence receptor affinity and biological function, allowing VEGF-D to participate in distinct aspects of vascular signaling. The protein forms homodimers, and its maturation is an important regulatory mechanism controlling VEGFR activation.
VEGF-D signaling through VEGFR-3 promotes lymphatic endothelial cell proliferation, migration, and survival. These activities contribute to lymphatic vessel development, tissue fluid balance, and responses to injury or inflammation. Mature VEGF-D can also activate VEGFR-2, supporting angiogenic responses and vascular remodeling. The VEGF-D Polyclonal Antibody is relevant to research investigating these signaling pathways and the molecular mechanisms governing endothelial cell behavior. VEGF-D activity is further influenced by its availability in the extracellular environment and interactions with regulatory proteins that affect receptor engagement.
VEGFD has attracted considerable interest in cancer research because lymphatic vessel growth can facilitate the movement of tumor cells toward regional lymph nodes. Increased VEGF-D expression has been associated with lymphangiogenesis and lymphatic metastasis in several tumor types, although its biological significance varies with tumor context and receptor expression. VEGF-D is also investigated in cardiovascular biology, where its effects on endothelial signaling and vessel remodeling may contribute to tissue repair and vascular adaptation. These functions highlight the importance of VEGF-D in both physiological and pathological vascular processes.
Research involving VEGF-D examines the regulation of vascular growth, lymphatic function, tumor-associated lymphangiogenesis, and receptor-mediated signaling. Understanding the relationship between VEGF-D processing and VEGFR activation is important for interpreting its biological effects. NSJ Bioreagents offers antibodies targeting VEGFD for studies of vascular and lymphatic biology. A VEGFD Antibody provides a research tool for investigating VEGF-D expression and its involvement in endothelial signaling, angiogenesis, lymphangiogenesis, and cancer progression.
Explore our Cancer Marker Antibodies collection for additional antibodies targeting proteins involved in tumor angiogenesis, lymphangiogenesis, and cancer progression.
Optimal dilution of the VEGFD Antibody / VEGF-D Polyclonal Antibody should be determined by the researcher.
Amino acids 89-205 of human VEGFD were used as the immunogen for the VEGFD antibody.
After reconstitution, the VEGFD antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
VEGF-D antibody, VEGF4 antibody, FIGF antibody, C-fos Induced Growth Factor antibody, Vascular Endothelial Growth Factor D antibody, VEGFD Protein antibody
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