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Home >> Antibodies >> VEGF-A Antibody

VEGF-A Antibody (F41972)

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  Catalog No Formulation Size Price (USD)  
Image F41972-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F41972-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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VEGF-A antibody western blot analysis in K562 lysate. Expected molecular weight 19~22 kDa (monomer) and 38~44 kDa (dimer). Banding may appear larger than predicted due to glycosylation.
VEGF-A antibody western blot analysis in K562 lysate. Expected molecular weight 19~22 kDa (monomer) and 38~44 kDa (dimer). Banding may appear larger than predicted due to glycosylation.
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P15692
Applications Western blot : 1:1000
Limitations This VEGF-A antibody is available for research use only.
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Description

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms.

Application Notes

Titration of the VEGF-A antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

A portion of amino acids 140-168 from the human protein was used as the immunogen for this VEGF-A antibody.

Storage

Aliquot the VEGF-A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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