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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
VE Cadherin Antibody / Cadherin 5 / CDH5 (RQ4336)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ4336 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | P55284 |
| Localization | Cell junction |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml ELISA (Capture; Mouse Recombinant Protein) : 1-5ug/ml |
| Limitations | This VE Cadherin antibody is available for research use only. |
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VE Cadherin Antibody / Cadherin 5 recognizes Cadherin 5, a calcium-dependent cell adhesion protein that is selectively expressed in endothelial cells and plays a central role in vascular integrity. Cadherin 5 is encoded by the CDH5 gene and is a key component of adherens junctions, where it mediates homophilic cell-cell adhesion between neighboring endothelial cells. Through these junctions, VE Cadherin helps maintain endothelial barrier function and coordinates vascular stability under both physiological and pathological conditions.
Cadherin 5, also widely referred to as vascular endothelial cadherin or VE-cadherin in the literature, is a transmembrane protein belonging to the classical cadherin family. Its extracellular domain facilitates calcium-dependent adhesion, while the cytoplasmic tail interacts with catenins and the actin cytoskeleton to link cell junctions to intracellular signaling and structural networks. This organization allows VE Cadherin to integrate mechanical forces and signaling cues within the vascular endothelium.
Expression of VE Cadherin is largely restricted to endothelial cells lining blood and lymphatic vessels, making it one of the most specific markers for endothelial identity. As a result, VE Cadherin antibody is frequently used to visualize endothelial cell junctions and vascular structures in tissue sections. In immunohistochemical and immunofluorescence studies, Cadherin 5 typically localizes to the cell membrane at sites of cell-cell contact, reflecting its role in adherens junction formation and maintenance.
Cadherin 5 plays important roles in angiogenesis, vascular remodeling, and endothelial permeability regulation. Alterations in VE Cadherin expression or junctional organization have been associated with inflammation, tumor angiogenesis, and vascular dysfunction. Because of its involvement in endothelial signaling and barrier control, Cadherin 5 has been extensively studied in cardiovascular research, cancer biology, and inflammatory disease models. Use of a VE Cadherin antibody supports investigation of endothelial junction dynamics and vascular biology across diverse experimental systems.
VE Cadherin Antibody / Cadherin 5 is designed to detect Cadherin 5 in research applications. Detection of CDH5 expression enables assessment of endothelial cell distribution, vascular architecture, and junctional organization in cell- and tissue-based studies. Overall, Cadherin 5 remains a foundational endothelial marker and a critical protein for understanding vascular development, maintenance, and disease-associated changes.
Optimal dilution of the VE Cadherin antibody should be determined by the researcher.
A recombinant mouse protein corresponding to amino acids D46-E285 was used as the immunogen for the VE Cadherin antibody.
After reconstitution, the VE Cadherin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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