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Home >> Antibodies >> VDR Antibody

VDR Antibody (F46490)

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  Catalog No Formulation Size Price (USD)  
Image F46490-0.4ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.4 ml 399
Image
F46490-0.08ML In 1X PBS, pH 7.4, with 0.09% sodium azide 0.08 ml 185
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VDR antibody western blot analysis in HL-60 lysate. Predicted molecular weight 48/54 kDa (isoforms 1/2).
VDR antibody western blot analysis in HL-60 lysate. Predicted molecular weight 48/54 kDa (isoforms 1/2).
Availability 1-3 business days
Species Reactivity Human
Format Antigen affinity purified
Clonality Polyclonal (rabbit origin)
Isotype Rabbit Ig
Purity Antigen affinity
UniProt P11473
Applications Western blot : 1:1000
Limitations This VDR antibody is available for research use only.
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Description

This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.

Application Notes

Titration of the VDR antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Immunogen

This VDR antibody was produced from rabbits immunized with a recombinant protein of human VDR.

Storage

Aliquot the VDR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

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