- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Uroplakin 1A Antibody Recombinant Rabbit MAb / UPK1A [clone UPK1A/8704R] (V4630)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V4630-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4630-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4630SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Rabbit |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG, kappa |
| Clone Name | UPK1A/8704R |
| Purity | Protein A/G affinity |
| UniProt | O00322 |
| Localization | Cell Surface |
| Applications | ELISA (Order BSA-free Format For Coating) : Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT |
| Limitations | This Uroplakin 1A antibody is available for research use only. |
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Uroplakin 1A antibody recognizes Uroplakin 1A, a transmembrane protein encoded by the UPK1A gene and a key structural component of the urothelial apical membrane. Uroplakin 1A Antibody Recombinant Rabbit MAb (clone UPK1A/8704R) is developed for research applications focused on detecting this differentiation-associated protein in urothelial tissues. Uroplakin 1A is localized to the apical plasma membrane of umbrella cells lining the urinary bladder and other parts of the urinary tract, where it contributes to formation of specialized urothelial plaques that support barrier integrity.
Uroplakin 1A antibody, also referred to as UPK1A antibody and UPIa antibody in the literature, targets a member of the uroplakin family that forms heterodimeric complexes with other uroplakin proteins. Uroplakin 1A contains multiple transmembrane domains and extracellular loops that participate in assembly of asymmetric unit membrane plaques. These plaques provide mechanical strength and create a highly impermeable surface, protecting underlying tissues from urine toxicity and osmotic stress.
UPK1A expression is highly restricted to differentiated urothelial umbrella cells in the bladder, ureter, and renal pelvis. Its expression is associated with terminal urothelial differentiation and maintenance of epithelial polarity. Because of this tissue-specific distribution, Uroplakin 1A is widely studied as a marker of urothelial lineage and differentiation status.
In oncology research, UPK1A expression is commonly evaluated in urothelial carcinoma and in the differential diagnosis of metastatic tumors of unknown primary origin. Membranous staining of Uroplakin 1A can support identification of urothelial differentiation in carcinoma specimens, while most non-urothelial epithelial tumors are negative. This selective expression profile makes Uroplakin 1A antibody useful for studies of bladder cancer biology and tumor classification in tissue-based analyses.
The recombinant rabbit monoclonal clone UPK1A/8704R provides specific recognition of Uroplakin 1A for research use, enabling visualization of urothelial differentiation patterns and investigation of urinary tract epithelial biology at NSJ Bioreagents.
Optimal dilution of the Uroplakin 1A antibody recombinant rabbit mAb should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 100-200) from the human protein was used as the immunogen for the Uroplakin 1A antibody recombinant rabbit mAb.
Aliquot the Uroplakin 1A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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