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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
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Uroplakin 1B (UPK1B) is a multi-pass transmembrane protein encoded by the UPK1B gene and is a defining structural component of urothelial plaques that line the apical surface of bladder epithelial cells. UPK1B Antibody / Urothelial Plaque Structural Protein Antibody (clone UPK1B/3102) recognizes this protein in the context of plaque architecture, where it is commonly referred to as Uroplakin 1B antibody or UP1B antibody in the literature. This Urothelial Plaque Structural Protein Antibody highlights UPK1B as an integral building block of the asymmetric unit membrane, forming the rigid, highly organized plaque structures characteristic of differentiated umbrella cells. As a Urothelial Plaque Structural Protein Antibody, it emphasizes the structural framework that defines the urothelial apical membrane rather than broader epithelial identity.
UPK1B functions within the uroplakin complex, assembling with UPK1A, UPK2, and UPK3A to generate the hexagonally arranged protein arrays that create urothelial plaques. These complexes form highly ordered crystalline-like structures that cover the apical surface of umbrella cells, providing mechanical strength and maintaining membrane organization during bladder filling and distension. This Urothelial Plaque Structural Protein Antibody is therefore particularly suited for studying plaque assembly, protein complex formation, and the ultrastructural organization of urothelial membranes, rather than focusing on differentiation marker applications.
The defining feature of UPK1B biology is its contribution to plaque structure, where tightly packed uroplakin complexes generate a rigid membrane domain distinct from typical lipid bilayers. This specialized architecture supports the unique morphology of umbrella cells and creates a highly organized surface environment. This Urothelial Plaque Structural Protein Antibody reinforces that structural role, separating it clearly from UPK1B antibody formats that emphasize differentiation state or epithelial barrier function. By centering on plaque formation, this page establishes a distinct biological identity aligned with membrane ultrastructure and protein assembly.
UPK1B expression is largely restricted to urothelial tissues including bladder, ureter, and renal pelvis, with localization concentrated at the apical membrane of superficial umbrella cells where plaque structures are most abundant. Staining is typically observed as strong membranous labeling corresponding to dense uroplakin plaque regions. Clone UPK1B/3102 antibody provides consistent recognition of UPK1B, and the UPK1B/3102 monoclonal antibody format supports reproducible detection of this urothelial plaque structural protein in studies focused on membrane architecture and epithelial ultrastructure.
Optimal dilution of the UPK1B Antibody / Urothelial Plaque Structural Protein Antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 109-229) was used at the immunogen for this UPK1B Antibody / Urothelial Plaque Structural Protein Antibody.
Store the UPK1B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Uroplakin 1B antibody, UP1B antibody, Tspan20 antibody, Urothelial plaque protein antibody
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