- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
UPK1A Antibody Mouse Monoclonal / Uroplakin 1A [clone TTSP21-1] (V8002)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V8002-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 100 ug | 559 | |
|
|
V8002-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide | 20 ug | 259 | |
|
|
V8002SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
|
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | TTSP21-1 |
| Purity | Protein G affinity chromatography |
| UniProt | O00322 |
| Localization | Cell surface, cytoplasmic |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This UPK1A antibody is available for research use only. |
|
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Uroplakin 1A antibody recognizes Uroplakin 1A, a urothelial differentiation-associated membrane protein encoded by the UPK1A gene. Uroplakin 1A Antibody Mouse Monoclonal (clone TTSP21-1) is developed for research applications requiring detection of this apical membrane component in urothelial tissues. Uroplakin 1A localizes predominantly to the apical plasma membrane of umbrella cells lining the urinary bladder, ureter, and renal pelvis, where it contributes to formation of specialized urothelial plaques that maintain barrier integrity and epithelial polarity.
Uroplakin 1A antibody, also referred to as UPK1A antibody and UPIa antibody in the literature, targets a member of the uroplakin family of integral membrane proteins. Uroplakin 1A contains multiple transmembrane domains and extracellular loops that participate in heterodimer formation with Uroplakin 2. These complexes assemble into asymmetric unit membrane plaques that provide mechanical stability and reduce permeability of the urothelial surface to urine and solutes. This structural organization is essential for protecting underlying tissues from osmotic stress and toxic metabolites.
UPK1A expression is highly restricted to differentiated urothelial umbrella cells and is closely associated with terminal epithelial differentiation and maintenance of apical polarity. Because of this tissue-specific expression pattern, Uroplakin 1A is widely studied as a marker of urothelial lineage in both normal tissue biology and tumor classification research. Membranous staining patterns are particularly informative in immunohistochemical evaluation of bladder and upper urinary tract tissues.
In oncology research, UPK1A expression is commonly assessed in urothelial carcinoma and in the differential diagnosis of metastatic carcinomas of unknown primary origin. Detection of Uroplakin 1A supports urothelial differentiation, while most non-urothelial epithelial tumors lack expression. This selective distribution profile makes Uroplakin 1A antibody valuable for studies of bladder cancer biology and epithelial lineage determination.
The mouse monoclonal clone TTSP21-1 provides targeted recognition of Uroplakin 1A for research use, supporting investigation of urothelial differentiation patterns and urinary tract epithelial biology at NSJ Bioreagents.
The stated application concentrations are suggested starting points. Titration of the UPK1A antibody mouse monoclonal may be required due to differences in protocols and secondary/substrate sensitivity.
Amino acids 114-173 were used as the immunogen for the UPK1A antibody mouse monoclonal.
Store the UPK1A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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