- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
UPF1 Antibody / Up-frameshift suppressor 1 / RENT1 [clone 19U80] (RQ8947)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ8947 | Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Mouse |
| Clonality | Recombinant Rabbit Monoclonal |
| Isotype | Rabbit IgG |
| Clone Name | 19U80 |
| Purity | Affinity purified |
| UniProt | Q92900 |
| Localization | Cytoplasmic, Nuclear |
| Applications | Western Blot : 1:1000 Immunohistochemistry (FFPE) : 1:50 |
| Limitations | This UPF1/Up-frameshift suppressor 1 antibody is available for research use only. |
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UPF1 antibody, also known as Up-frameshift suppressor 1 antibody, recognizes a highly conserved RNA helicase and ATPase encoded by the human UPF1 gene located on chromosome 19p13.11. Up-frameshift suppressor 1 is a predominantly cytoplasmic protein that shuttles between the nucleus and cytoplasm and plays a central role in nonsense-mediated mRNA decay, commonly referred to as NMD. UPF1 antibody targets a core component of the NMD surveillance pathway that identifies and degrades mRNAs containing premature termination codons, thereby preventing the production of truncated or potentially harmful proteins.
Up-frameshift suppressor 1 is a member of the superfamily 1 helicase family and contains characteristic RNA helicase domains, including ATP-binding and RNA-binding motifs that enable ATP-dependent unwinding of RNA substrates. It interacts with additional NMD factors such as UPF2 and UPF3 to form a surveillance complex associated with translating ribosomes. Following recognition of aberrant termination events, Up-frameshift suppressor 1 undergoes regulated phosphorylation that promotes recruitment of decay machinery and subsequent mRNA degradation. In addition to NMD, UPF1 participates in general mRNA turnover, Staufen-mediated decay, and regulation of specific transcripts involved in cell growth and stress responses.
UPF1 is widely expressed across tissues, reflecting its fundamental role in RNA quality control. Elevated or altered UPF1 activity has been implicated in cancer biology, viral infection, and neurodevelopmental disorders, where dysregulated RNA surveillance can influence transcript stability and gene expression programs. Structurally, Up-frameshift suppressor 1 contains a cysteine-histidine rich domain and helicase core domains that coordinate ATP hydrolysis with RNA remodeling activity. Its subcellular localization is primarily cytoplasmic, often associated with processing bodies and sites of active translation.
UPF1 antibody is suitable for detecting Up-frameshift suppressor 1 expression in studies of RNA surveillance, mRNA decay pathways, and translational control. By enabling analysis of UPF1 levels and distribution, this antibody supports research into post-transcriptional gene regulation and disease-associated alterations in RNA metabolism.
Optimal dilution of the UPF1/Up-frameshift suppressor 1 antibody should be determined by the researcher.
A peptide specific to Up-frameshift suppressor 1 protein was used as the immunogen for the UPF1/Up-frameshift suppressor 1 antibody.
After reconstitution, the UPF1/Up-frameshift suppressor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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