uPAR Antibody | Cell Invasion Receptor Antibody

	Catalog No	Formulation	Size	Price (USD)
	RQ4361	0.5mg/ml if reconstituted with 0.2ml sterile DI water	100 ug	449
Formulation

uPAR Antibody Mouse Kidney IHC. Immunohistochemical staining of FFPE mouse kidney tissue using uPAR Antibody at 2 ug/ml. HIER was performed in pH 8.0 EDTA buffer. An HRP-conjugated goat anti-rabbit IgG secondary antibody with DAB substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates strong membranous and cytoplasmic staining in renal tubular epithelial cells, consistent with the role of PLAUR/uPA receptor in extracellular matrix remodeling, cell migration, and tissue remodeling processes.

uPAR Antibody Rat Kidney IHC. Immunohistochemical staining of FFPE rat kidney tissue using uPAR Antibody at 2 ug/ml. HIER was performed in pH 8.0 EDTA buffer. An HRP-conjugated goat anti-rabbit IgG secondary antibody with DAB substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates strong membranous and cytoplasmic staining in renal tubular epithelial cells, consistent with the role of PLAUR/uPA receptor in extracellular matrix remodeling, cell migration, and tissue remodeling processes.

uPAR Antibody Mouse and Rat Tissue WB. Western blot analysis of rat brain, rat heart, rat C6, mouse brain, mouse thymus, mouse heart, and mouse RAW264.7 lysates using uPAR Antibody at 0.5 ug/ml. An HRP-conjugated secondary antibody with ECL substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, detects a prominent band at approximately 50 kDa across multiple rat and mouse samples, consistent with the glycosylated form of PLAUR/uPA receptor. The higher observed molecular weight compared to the predicted 36 kDa core protein is consistent with extensive post-translational glycosylation of uPAR.

uPAR Antibody Rat PC-12 Cell FACS. Flow cytometric analysis of fixed and permeabilized rat PC-12 cells using uPAR Antibody at 1 ug/million cells. Cells were blocked with normal goat serum and detected with a DyLight 488-conjugated goat anti-rabbit IgG secondary antibody. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates a clear positive shift compared to isotype control, confirming detection of PLAUR/uPA receptor expression in PC-12 cells and supporting its use for analysis of uPAR-mediated signaling, cell migration, and tissue remodeling pathways.

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uPAR Antibody Mouse Kidney IHC. Immunohistochemical staining of FFPE mouse kidney tissue using uPAR Antibody at 2 ug/ml. HIER was performed in pH 8.0 EDTA buffer. An HRP-conjugated goat anti-rabbit IgG secondary antibody with DAB substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates strong membranous and cytoplasmic staining in renal tubular epithelial cells, consistent with the role of PLAUR/uPA receptor in extracellular matrix remodeling, cell migration, and tissue remodeling processes.

uPAR Antibody Rat Kidney IHC. Immunohistochemical staining of FFPE rat kidney tissue using uPAR Antibody at 2 ug/ml. HIER was performed in pH 8.0 EDTA buffer. An HRP-conjugated goat anti-rabbit IgG secondary antibody with DAB substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates strong membranous and cytoplasmic staining in renal tubular epithelial cells, consistent with the role of PLAUR/uPA receptor in extracellular matrix remodeling, cell migration, and tissue remodeling processes.

uPAR Antibody Mouse and Rat Tissue WB. Western blot analysis of rat brain, rat heart, rat C6, mouse brain, mouse thymus, mouse heart, and mouse RAW264.7 lysates using uPAR Antibody at 0.5 ug/ml. An HRP-conjugated secondary antibody with ECL substrate was used for detection. uPAR Antibody, a Cell Invasion Receptor Antibody, detects a prominent band at approximately 50 kDa across multiple rat and mouse samples, consistent with the glycosylated form of PLAUR/uPA receptor. The higher observed molecular weight compared to the predicted 36 kDa core protein is consistent with extensive post-translational glycosylation of uPAR.

uPAR Antibody Rat PC-12 Cell FACS. Flow cytometric analysis of fixed and permeabilized rat PC-12 cells using uPAR Antibody at 1 ug/million cells. Cells were blocked with normal goat serum and detected with a DyLight 488-conjugated goat anti-rabbit IgG secondary antibody. uPAR Antibody, a Cell Invasion Receptor Antibody, demonstrates a clear positive shift compared to isotype control, confirming detection of PLAUR/uPA receptor expression in PC-12 cells and supporting its use for analysis of uPAR-mediated signaling, cell migration, and tissue remodeling pathways.

Availability	1-3 business days
Species Reactivity	Mouse, Rat
Format	Antigen affinity purified
Host	Rabbit
Clonality	Polyclonal (rabbit origin)
Isotype	Rabbit IgG
Purity	Antigen affinity purified
Buffer	Lyophilized from 1X PBS with 2% Trehalose
UniProt	P49616
Localization	Cell membrane
Applications	Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml
Limitations	This uPAR Antibody / Cell Invasion Receptor Antibody is available for research use only.
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Description

uPAR Antibody recognizes urokinase plasminogen activator receptor (uPAR/CD87), a glycosylphosphatidylinositol (GPI)-anchored cell surface receptor encoded by the PLAUR gene. uPAR binds urokinase-type plasminogen activator (uPA) and localizes plasmin generation to the cell surface, promoting extracellular matrix degradation, tissue remodeling, and cellular migration. In addition to regulating proteolysis, uPAR interacts with integrins, vitronectin, and multiple signaling receptors to influence adhesion, survival, and intracellular signaling pathways. Due to its central role in cell motility and tissue remodeling, uPAR Antibody is widely used to study cancer progression, inflammatory responses, and mechanisms controlling cellular invasion.

uPAR expression is normally associated with activated immune cells, endothelial cells, fibroblasts, and tissues undergoing repair or remodeling. Increased PLAUR expression has been reported in numerous cancers, including breast, colorectal, lung, pancreatic, ovarian, and brain tumors, where it is associated with tumor invasion, epithelial-mesenchymal transition, angiogenesis, metastasis, and poor clinical outcomes. By regulating pericellular proteolysis and interactions with the tumor microenvironment, uPAR contributes to many processes required for malignant progression. As a Cell Invasion Receptor Antibody, uPAR Antibody is valuable for investigating tumor biology and mechanisms that drive cancer cell migration.

Beyond oncology, uPAR participates in immune regulation, wound healing, inflammation, and vascular biology. Expression of uPAR on monocytes, macrophages, neutrophils, and other immune populations influences leukocyte recruitment, cytokine responses, and inflammatory signaling. Soluble uPAR (suPAR), generated through receptor cleavage, has also gained attention as a biomarker associated with immune activation, chronic inflammation, kidney disease, cardiovascular disorders, and infection severity. These diverse functions highlight the importance of PLAUR in both normal physiology and disease processes.

uPAR Antibody, a Cell Invasion Receptor Antibody, provides a valuable tool for studying extracellular matrix remodeling, protease signaling, tumor invasion, and inflammatory responses. Researchers use uPAR Antibody to investigate cancer metastasis, cell migration, immune cell activation, angiogenesis, and the molecular pathways that regulate tissue remodeling and disease progression.

Explore additional Cancer Antibodies for targets involved in tumor invasion, extracellular matrix remodeling, metastasis, and cancer cell signaling.

Application Notes

Optimal dilution of the uPAR Antibody / Cell Invasion Receptor Antibody should be determined by the researcher.

Immunogen

A recombinant rat protein corresponding to amino acids L25-R261 was used as the immunogen for the uPAR antibody.

Storage

After reconstitution, the uPA Receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Alternate Names

CD87 Antibody, PLAUR Antibody, Urokinase Receptor Antibody, Urokinase Plasminogen Activator Receptor Antibody, uPA Receptor Antibody, Cell Migration Receptor Antibody

uPAR Antibody / Cell Invasion Receptor Antibody (RQ4361)

Description

Application Notes

Immunogen

Storage

Alternate Names

Area of Research

Product Type

Protocols

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NSJ Bioreagents