- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Ufm1-conjugating enzyme 1 Antibody / Ufc1 (F54767)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
F54767-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 429 | |
|
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F54767-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 199 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | Q9Y3C8 |
| Applications | Western Blot : 1:500-1:1000 Immunohistochemistry (FFPE) : 1:10-1:50 Flow Cytometry : 1:10-1:50 (1x10e6 cells) |
| Limitations | This Ufm1-conjugating enzyme 1 antibody is available for research use only. |
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Ufm1-conjugating enzyme 1 antibody targets Ufm1-conjugating enzyme 1, encoded by the UFC1 gene. UFC1 is a cytoplasmic enzyme that functions as the E2 component of the UFM1 conjugation system, a ubiquitin-like modification pathway that regulates protein homeostasis and cellular stress responses. In this pathway, UFC1 transfers activated UFM1 from the E1 enzyme UBA5 to downstream substrates in coordination with the E3 ligase UFL1, enabling covalent ufmylation of target proteins.
Functionally, Ufm1-conjugating enzyme 1 plays a central role in maintaining endoplasmic reticulum integrity and regulating responses to proteotoxic and oxidative stress. UFC1-dependent ufmylation has been linked to ER-associated processes, ribosome quality control, and regulation of protein secretion. Through these activities, UFC1 contributes to cellular adaptation under conditions that challenge protein folding and trafficking, making it an important node in stress signaling pathways. A Ufm1-conjugating enzyme 1 antibody supports studies focused on ufmylation dynamics and stress-regulated protein modification.
UFC1 is broadly expressed across tissues, reflecting the fundamental role of the UFM1 system in cell viability. Its activity is particularly relevant in secretory and metabolically active cells, where ER stress must be tightly controlled. UFC1 interacts with multiple components of the ufmylation machinery, forming transient enzyme-substrate complexes that enable precise regulation of UFM1 transfer.
From a disease perspective, altered ufmylation signaling has been associated with cancer, neurodevelopmental disorders, and inflammatory conditions. Disruption of UFC1 function can impair ER homeostasis and protein quality control, contributing to pathological cellular states. As a result, UFC1 is increasingly studied in the context of diseases linked to stress signaling and protein modification pathways.
At the molecular level, Ufm1-conjugating enzyme 1 contains conserved catalytic residues required for thioester bond formation with UFM1, a defining feature of E2 enzymes. The apparent behavior of UFC1 in biochemical assays may be influenced by enzyme conformation, interacting partners, or modification state. Ufm1-conjugating enzyme 1 antibody reagents enable research applications focused on ufmylation, ER stress biology, and protein quality control, with NSJ Bioreagents providing reagents intended for research use only.
The stated application concentrations are suggested starting points. Titration of the Ufm1-conjugating enzyme 1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
An amino acid sequence from the C-terminal region of the human protein was used as the immunogen for the Ufm1-conjugating enzyme 1 antibody.
Aliquot the Ufm1-conjugating enzyme 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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