- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TYSY Antibody / Thymidylate Synthase (F54872)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F54872-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F54872-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity purified |
| UniProt | P04818 |
| Localization | Cytoplasmic, nuclear |
| Applications | Western blot : 1:500-1:1000 Immunofluorescence : 1:10-1:50 Flow cytometry : 1:10-1:50 (1x10e6 cells) Immunohistochemistry (FFPE) : 1:50-1:100 |
| Limitations | This TYSY antibody is available for research use only. |
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Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.
The stated application concentrations are suggested starting points. Titration of the TYSY antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 265-294 from the human protein was used as the immunogen for the TYSY antibody.
Aliquot the TYSY antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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