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Home >> Antibodies >> TYRP1 Antibody / TRP1 / Tyrosinase-Related Protein-1 Antibody

TYRP1 Antibody / TRP1 / Tyrosinase-Related Protein-1 Antibody [clone TYRP1/807] (V2916)

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  Catalog No Formulation Size Price (USD)  
Image V2916-100UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 100 ug 519
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V2916-20UG 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide 20 ug 229
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V2916SAF-100UG 1 mg/ml in 1X PBS; BSA free, sodium azide free 100 ug 519
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V2916IHC-7ML Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only* 7 ml 519
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IHC: Formalin-fixed, paraffin-embedded human melanoma stained with TYRP1 antibody (clone TYRP1/807). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
IHC: Formalin-fixed, paraffin-embedded human melanoma stained with TYRP1 antibody (clone TYRP1/807). Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
Availability 1-3 business days
Species Reactivity Human
Format Purified
Clonality Monoclonal (mouse origin)
Isotype Mouse IgG2a, kappa
Clone Name TYRP1/807
Purity Protein G affinity chromatography
UniProt P17643
Localization Cytoplasmic
Applications Immunohistochemistry (FFPE) : 3-6ug/ml for 30 min at RT
Limitations This TYRP1 antibody is available for research use only.
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Description

It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.

Application Notes

Optimal dilution of the TYRP1 antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Immunogen

Recombinant full-length human protein was used as the immunogen for the TYRP1 antibody.

Storage

Store the TYRP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

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