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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tyrosine Hydroxylase Antibody / TH (R36337)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
R36337-100UG | 0.5 mg/ml in 1X TBS, pH7.3, with 0.5% BSA (US sourced) and 0.02% sodium azide | 100 ug | 475 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Predicted Reactivity | Rat, Dog |
| Format | Antigen affinity purified |
| Host | Goat |
| Clonality | Polyclonal (goat origin) |
| Isotype | Goat Ig |
| Purity | Antigen affinity |
| Gene ID | 7054 |
| Applications | Western Blot : 2-4ug/ml IHC (Frozen) : 0.1-0.3ug/ml ELISA (peptide) LOD : 1:8000 |
| Limitations | This Tyrosine Hydroxylase antibody is available for research use only. |
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Tyrosine Hydroxylase Antibody recognizes Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis and a highly specific marker of dopaminergic and noradrenergic neurons. Tyrosine hydroxylase antibody, also widely referred to as TH antibody in neuroscience literature, targets the TH gene product responsible for catalyzing the conversion of L-tyrosine to L-DOPA, the first and regulatory step in the synthesis of dopamine, norepinephrine, and epinephrine. Because of this central biochemical role, Tyrosine Hydroxylase Antibody is extensively used as a marker of catecholaminergic neurons in the central and peripheral nervous systems.
Tyrosine hydroxylase is primarily localized to the cytoplasm of neurons in the substantia nigra pars compacta, ventral tegmental area, locus coeruleus, and sympathetic ganglia. In addition to neurons, TH expression can be detected in adrenal medullary chromaffin cells, where catecholamines are synthesized and secreted into circulation. Tyrosine Hydroxylase Antibody therefore serves as a robust tool for identifying dopaminergic neurons, sympathetic fibers, and neuroendocrine cells in both experimental and translational research settings.
At the molecular level, Tyrosine hydroxylase is a tetrahydrobiopterin-dependent monooxygenase regulated by phosphorylation at multiple serine residues. These phosphorylation events modulate enzymatic activity and catecholamine production in response to neuronal stimulation and stress. Altered TH expression or activity has been implicated in neurologic disorders including Parkinson disease, where loss of TH-positive neurons in the substantia nigra correlates with dopamine deficiency. Reduced TH immunoreactivity is commonly used as a readout of dopaminergic neuron degeneration in experimental models of neurotoxicity and neurodegeneration.
In oncology and pathology research, Tyrosine Hydroxylase Antibody is also used to evaluate neuroblastoma, pheochromocytoma, and other catecholamine-producing tumors. Nuclear staining is not expected, as Tyrosine hydroxylase is a cytoplasmic enzyme; immunohistochemical labeling typically appears as granular cytoplasmic staining in positive cells. Clone-specific reagents such as TH antibody clones are designed to detect endogenous Tyrosine hydroxylase protein in research applications and provide clear visualization of catecholaminergic cell populations.
By targeting the key enzyme in catecholamine biosynthesis, Tyrosine Hydroxylase Antibody remains an essential reagent for studies of dopamine signaling, autonomic nervous system biology, stress responses, and neurodegenerative disease mechanisms.
Optimal dilution of the Tyrosine Hydroxylase antibody should be determined by the researcher.
Amino acids VQDELDTLAHAL were used as the immunogen for this Tyrosine Hydroxylase antibody.
Aliquot and store the Tyrosine Hydroxylase antibody at -20oC.
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