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- Tel: 858.663.9055
- Email: info@nsjbio.com
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It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1). It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi.Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.
A recombinant human partial protein (amino acids 257-377) was used as the immunogen for this TRP1 antibody.
Store the Tyrosinase-Related Protein-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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