- Tel: 858.663.9055
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Tuberin Antibody (F49604)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
 |
F49604-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 399 | |
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F49604-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 185 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | P49815 |
| Applications | Immunofluorescence : 1:10-1:50 Western blot : 1:1000 IHC (Paraffin) : 1:10-1:50 |
| Limitations | This Tuberin antibody is available for research use only. |
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Mutations in TSC2 lead to tuberous sclerosis complex. This protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Titration of the Tuberin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 1776-1805 from the human protein was used as the immunogen for this Tuberin antibody.
Aliquot the Tuberin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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