- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TTF-1 Antibody / Nuclear Homeobox Transcription Factor Antibody [clone TTF1/8430] (V4344)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4344-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
|
|
V4344-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
|
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V4344SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | TTF1/8430 |
| Purity | Protein A/G affinity |
| UniProt | P43699 |
| Localization | Nucleus |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This TTF-1 antibody is available for research use only. |
|
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Thyroid transcription factor 1 (NKX2-1) is a nuclear homeobox transcription factor belonging to the NKX2 family of DNA-binding transcriptional regulators that control gene expression programs during tissue development and epithelial lineage specification. The protein contains a conserved homeobox DNA-binding domain that enables sequence-specific interaction with regulatory regions of target genes. The TTF-1 Antibody / Nuclear Homeobox Transcription Factor Antibody recognizes this nuclear transcription factor, which localizes to the nucleus where it regulates transcription of genes involved in epithelial differentiation and organ development.
TTF-1 antibody, also referred to as NKX2-1 antibody or Thyroid transcription factor 1 antibody in the literature, detects a nuclear homeobox transcription factor that functions as a transcriptional regulator of tissue-specific gene expression. Homeobox transcription factors represent a major class of developmental regulators that control cellular identity by activating or repressing gene transcription. NKX2-1 operates within the nucleus as a DNA-binding transcription factor that modulates expression of genes involved in epithelial lineage determination and tissue-specific differentiation.
As a member of the NKX2 transcription factor family, NKX2-1 participates in transcriptional regulatory networks that coordinate gene expression programs during organogenesis. The protein binds promoter and enhancer regions of target genes and recruits transcriptional regulatory complexes that control transcriptional activity. Through these mechanisms, NKX2-1 acts as a nuclear transcription factor that governs developmental signaling pathways and regulates epithelial gene expression programs.
During embryonic development, NKX2-1 expression appears early within developing lung and thyroid primordia and plays an essential role in establishing epithelial lineage identity in these tissues. The transcription factor regulates genes associated with respiratory epithelial differentiation as well as thyroid-specific gene expression. Because NKX2-1 functions as a nuclear homeobox transcription factor, it remains a key regulator of transcriptional programs that define epithelial cell identity.
Because of its role in transcriptional regulation, NKX2-1 is widely studied as a nuclear homeobox transcription factor controlling developmental gene expression and epithelial lineage specification. A TTF-1 antibody such as clone TTF1/8430 provides a valuable tool for research focused on nuclear transcription factor biology, homeobox gene regulation, and transcriptional control of epithelial differentiation pathways.
Optimal dilution of the TTF-1 Antibody / Nuclear Homeobox Transcription Factor Antibody should be determined by the researcher.
Recombinant human TTF-1 protein was used as the immunogen for the TTF-1 antibody.
Aliquot the TTF-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
NKX2-1 antibody, Thyroid transcription factor 1 antibody, TTF1 antibody, TITF1 antibody, Thyroid transcription factor antibody
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