- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TSLP Antibody / Thymic Stromal Lymphopoietin Antibody (F44506)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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F44506-0.4ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.4 ml | 439 | |
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F44506-0.08ML | In 1X PBS, pH 7.4, with 0.09% sodium azide | 0.08 ml | 205 |
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| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit Ig |
| Purity | Antigen affinity |
| UniProt | Q969D9 |
| Localization | Secreted |
| Applications | Western Blot : 1:1000 |
| Limitations | This TSLP Antibody / Thymic Stromal Lymphopoietin Antibody is available for research use only. |
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TSLP Antibody / Thymic Stromal Lymphopoietin Antibody recognizes thymic stromal lymphopoietin (TSLP), an epithelial-derived cytokine that regulates communication between barrier tissues and the immune system. Originally identified for its ability to support lymphocyte development, TSLP is now recognized as a master regulator of type 2 immunity and epithelial inflammatory responses. It is produced predominantly by epithelial cells of the skin, respiratory tract and gastrointestinal tract in response to allergens, infection, mechanical injury and inflammatory mediators. Because of its central role in immune activation, TSLP Antibody is widely used to investigate cytokine biology and inflammatory signaling.
TSLP exerts its biological effects by binding the TSLP receptor complex, composed of the TSLP receptor chain and the interleukin 7 receptor alpha chain. Activation of this receptor stimulates JAK-STAT signaling and promotes dendritic cell maturation while influencing T cells, mast cells, eosinophils, basophils and innate lymphoid cells. Through these coordinated actions, TSLP contributes to allergic sensitization, mucosal defense and tissue repair. Consequently, TSLP Antibody serves as an important reagent for studying epithelial-immune communication and cytokine-mediated regulation.
Abnormal TSLP expression has been implicated in asthma, atopic dermatitis, allergic rhinitis, eosinophilic esophagitis and other chronic inflammatory diseases. Growing evidence also links TSLP signaling to fibrosis, autoimmune disorders, infection and tumor biology, where its effects vary according to tissue context and the surrounding immune environment. Therapeutic strategies targeting the TSLP pathway have further increased interest in understanding its regulation and downstream signaling mechanisms, making TSLP an important target across immunology and translational research.
A TSLP Antibody is a valuable reagent for investigating epithelial cytokine biology, allergic inflammation and immune regulation. A Thymic Stromal Lymphopoietin Antibody supports studies of barrier immunity, cytokine signaling, asthma, atopic dermatitis and epithelial-immune interactions.
For an overview of TSLP biology and its role as an epithelial-derived cytokine that regulates barrier immunity and type 2 inflammatory responses, visit our TSLP Antibody / Epithelial Derived Cytokine Antibody page.
Titration of the TSLP Antibody / Thymic Stromal Lymphopoietin Antibody may be required due to differences in protocols and secondary/substrate sensitivity.
A portion of amino acids 101-130 from the human protein was used as the immunogen for this TSLP antibody.
Aliquot the TSLP antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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