- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TRP-1 Antibody / Tyrosinase-Related Protein-1 [clone SPM456] (V5508)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V5508-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 539 | |
|
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V5508-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 249 | |
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V5508SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 539 |
TRP-1 antibody recognizes tyrosinase-related protein 1, encoded by the TYRP1 gene. TRP-1 is a melanocyte-specific protein involved in melanin biosynthesis, where it contributes to eumelanin production and pigment stabilization. It is localized to melanosomes and works in concert with tyrosinase and TRP-2 to regulate pigmentation. Because of its restricted expression and importance in melanocytic differentiation, TRP-1 antibody is a crucial reagent in melanoma research, pigment biology, and dermatology.
Structurally, TRP-1 is a transmembrane glycoprotein with an intraluminal catalytic domain that binds metal ions and contributes to redox chemistry during melanin synthesis. Although its enzymatic activity is less pronounced than tyrosinase, TRP-1 stabilizes melanin intermediates and protects against oxidative damage. Its expression in melanocytes and melanoma cells has made it a valuable marker for diagnostic pathology and immunotherapy development.
The TRP-1 antibody clone SPM456 provides reliable and specific recognition of this melanocytic protein. Clone SPM456 has been cited in peer-reviewed studies focused on melanoma immunology, pigment regulation, and melanocyte development. Recombinant-grade performance ensures consistent results across lots, reducing variability and supporting long-term research efforts. Its specificity for melanocytic lineages makes it useful in both basic and applied studies.
Research using clone SPM456 has demonstrated how TRP-1 expression distinguishes melanocytic tumors from other neoplasms, aiding in accurate classification. In addition, TRP-1 serves as a target in vaccine development and adoptive T-cell therapies, since immune responses directed against this protein can eliminate melanoma cells. Detection with this antibody supports translational approaches aimed at enhancing immune recognition of melanomas. Beyond oncology, TRP-1 detection has advanced understanding of pigmentation disorders and genetic conditions such as oculocutaneous albinism.
NSJ Bioreagents provides this TRP-1 antibody to support melanoma research, pigment biology, and translational immunology. Alternate terms include TYRP1 antibody, tyrosinase-related protein 1 antibody, gp75 antibody, melanocyte differentiation antigen antibody, and melanosomal protein antibody.
Optimal dilution of the TRP-1 antibody should be determined by the researcher.
SK-MEL-23 cells were used as the immunogen for the TRP-1 antibody.
Aliquot the TRP-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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