- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TRNAU1AP Antibody / SECp43 Antibody (RQ7590)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7590 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q9NX07 |
| Applications | Western Blot : 0.5-1ug/ml Immunoprecipitation : 2ug per 500ug of lysate Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This TRNAU1AP Antibody / SECp43 Antibody is available for research use only. |
|
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TRNAU1AP Antibody recognizes tRNA selenocysteine 1-associated protein 1 (TRNAU1AP), an RNA-binding protein commonly known as SECp43. This protein participates in the specialized machinery responsible for selenocysteine incorporation during protein synthesis. Selenocysteine is often described as the 21st genetically encoded amino acid and is incorporated into a select group of proteins known as selenoproteins. These proteins perform important functions in antioxidant defense, thyroid hormone metabolism, redox signaling, and cellular homeostasis.
Unlike conventional amino acids, selenocysteine is encoded by the UGA codon, which normally functions as a translation termination signal. Its incorporation requires a specialized transfer RNA, designated tRNA[Ser]Sec, along with dedicated translation factors and regulatory RNA elements. SECp43 was identified as a protein associated with selenocysteine-specific tRNA and has been investigated for its contribution to the organization and function of the selenoprotein synthesis machinery.
TRNAU1AP contains RNA-associated structural features that support interactions with components of the selenocysteine incorporation pathway. SECp43 has been reported to associate with selenocysteine tRNA and other proteins involved in the maturation and utilization of this specialized transfer RNA. Through these interactions, it may influence the availability or functional organization of tRNA[Ser]Sec during translation. The precise contribution of TRNAU1AP to individual steps of selenoprotein biosynthesis remains an area of investigation.
Selenoprotein production depends on coordinated interactions among tRNA[Ser]Sec, the selenocysteine-specific elongation factor EEFSEC, SECIS-binding protein 2 (SECISBP2), and specialized RNA structures known as selenocysteine insertion sequence elements. These components enable ribosomes to reinterpret selected UGA codons as signals for selenocysteine incorporation. SECp43 is associated with this broader regulatory network and has been studied in relation to selenocysteine tRNA metabolism and translation efficiency.
Because selenoproteins contribute to oxidative stress protection and metabolic regulation, proteins associated with their synthesis are relevant to research involving cellular redox balance, selenium biology, and translational control. Important selenoprotein families include glutathione peroxidases, thioredoxin reductases, and iodothyronine deiodinases. Changes in the efficiency of selenocysteine incorporation can influence the production of these proteins and potentially affect cellular responses to oxidative and metabolic stress.
TRNAU1AP has also been investigated in the context of RNA-protein interactions and the assembly of specialized translation-associated complexes. Its association with selenocysteine tRNA provides a connection between RNA metabolism and the regulated synthesis of proteins containing this unusual amino acid. Understanding SECp43 function may help clarify how cells coordinate selenium availability, tRNA maturation, and translational machinery to maintain appropriate selenoprotein expression.
An TRNAU1AP Antibody from NSJ Bioreagents provides a research tool for investigating SECp43 and its involvement in selenocysteine tRNA metabolism, specialized translation, and selenoprotein biosynthesis.
Explore our Cell Biology Antibodies collection for additional research tools targeting RNA metabolism, protein synthesis, and other fundamental cellular processes.
Optimal dilution of the TRNAU1AP Antibody / SECp43 Antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids R21-E282) was used as the immunogen for the TRNAU1AP antibody.
After reconstitution, the TRNAU1AP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
tRNA selenocysteine 1-associated protein 1 antibody, SECp43 antibody, tRNA selenocysteine-associated protein 1 antibody, Selenocysteine tRNA-associated protein antibody, tRNA[Ser]Sec-associated protein antibody
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