- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TrkC Antibody / NTRK3 [clone NTRK3/7140] (V4396)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
V4396-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V4396-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V4396SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | NTRK3/7140 |
| Purity | Protein A/G affinity |
| UniProt | Q16288 |
| Localization | Membrane |
| Applications | Immunohistochemistry (FFPE) : 1-2ug/ml for 30 minutes at RT |
| Limitations | This TrkC antibody is available for research use only. |
|
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TrkC antibody, also known as NTRK3 antibody, recognizes a receptor tyrosine kinase commonly referred to as Neurotrophic tyrosine kinase receptor type 3, Tropomyosin receptor kinase C, and NT-3 receptor. The NTRK3 gene encodes a single-pass transmembrane neurotrophin receptor in the neurotrophic receptor tyrosine kinase family that is predominantly localized to the cell membrane, with ligand-induced internalization to endosomal compartments during signaling. TrkC is best known as the high-affinity receptor for neurotrophin-3 (NT-3), supporting neuronal survival, axon guidance, and synapse development during embryonic and postnatal nervous system maturation. High expression is commonly associated with neuronal lineages, including subsets of sensory neurons and central nervous system populations, with context-dependent expression reported in additional tissues and tumor settings.
Mechanistically, NT-3 binding promotes receptor dimerization and autophosphorylation, engaging canonical pathways such as MAPK-ERK, PI3K-AKT, and PLC-gamma signaling that regulate differentiation, cytoskeletal dynamics, and pro-survival transcriptional programs. Structurally, TrkC contains extracellular immunoglobulin-like domains involved in ligand binding, a transmembrane segment, and an intracellular kinase domain that mediates downstream signaling via adaptor recruitment. NTRK3 is located on human chromosome 15, and alternative splicing can generate receptor variants that differ in signaling capacity and trafficking behavior, which can influence observed staining patterns across cell types and developmental stages.
In cancer biology, NTRK3 is clinically relevant because oncogenic gene fusions involving NTRK3 can produce constitutively active kinase signaling that drives tumor growth in multiple solid tumor contexts. Beyond fusions, altered TrkC expression has been investigated for roles in invasion, differentiation state, and growth factor crosstalk, depending on cellular background and co-receptor networks. Clone NTRK3/7140 is designed to recognize TrkC in research applications and can be used to study NTRK3 expression patterns and neurotrophin pathway biology in relevant experimental models. A TrkC antibody is suitable for detecting receptor distribution and relative expression changes in tissue and cell-based assays used in life science research.
Optimal dilution of the TrkC antibody should be determined by the researcher.
A recombinant partial protein sequence (within amino acids 100-300) from the human protein was used as the immunogen for the TrkC antibody.
Aliquot the TrkC antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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