- Tel: 858.663.9055
-
Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TRIM71 Antibody / LIN41 (RQ7586)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ7586 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 449 |
| Availability | 1-3 business days |
| Species Reactivity | Human, Mouse, Rat |
| Format | Antigen affinity purified |
| Host | Rabbit |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Antigen affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose |
| UniProt | Q2Q1W2 |
| Localization | Cytoplasmic |
| Applications | Western Blot : 0.5-1ug/ml Immunohistochemistry (FFPE) : 2-5ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml Immunoprecipitation : 2ug per 500ug of lysate |
| Limitations | This TRIM71 antibody is available for research use only. |
|
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TRIM71 antibody targets Tripartite motif-containing protein 71 (TRIM71), also known as LIN41, a cytoplasmic RNA-binding E3 ubiquitin ligase that plays a key role in post-transcriptional gene regulation during development. TRIM71 is a member of the TRIM family and contains a RING finger domain, B-box motifs, a coiled-coil region, and C-terminal NHL repeats that mediate RNA binding and protein interactions. The protein localizes primarily to the cytoplasm and is enriched in RNA granules, consistent with its role in regulating mRNA stability and translation in a context-dependent manner.
Functionally, TRIM71 acts as a regulator of cell fate decisions by repressing the expression of specific target mRNAs involved in differentiation and cell cycle control. It is highly expressed in embryonic stem cells and early progenitor populations, where it supports maintenance of pluripotency and controlled proliferation. As cells differentiate, TRIM71 expression is typically downregulated, allowing activation of developmental gene expression programs. A TRIM71 antibody supports studies examining post-transcriptional regulation and developmental timing in cellular systems.
TRIM71 is an evolutionarily conserved target of the let-7 family of microRNAs, linking it to well-characterized regulatory networks that coordinate developmental progression. Through interactions with microRNA machinery and RNA-binding cofactors, TRIM71 can repress translation or promote degradation of bound transcripts. These mechanisms enable precise control of gene expression outputs during early development and tissue patterning. A TRIM71 antibody enables investigation of TRIM71 expression dynamics and subcellular localization in developmental and regulatory contexts.
From a biological and disease-relevance perspective, TRIM71 has been studied in relation to neurodevelopment, stem cell biology, and cancer-associated pathways. Dysregulated TRIM71 expression has been linked to altered proliferation and impaired differentiation, highlighting its importance in balancing growth and maturation programs. Its dual roles in RNA regulation and ubiquitin-mediated control position TRIM71 as an integrative regulator of gene expression networks.
At the molecular level, TRIM71 is encoded by the TRIM71 gene and produces a protein of approximately 868 amino acids. The N-terminal RING domain confers E3 ubiquitin ligase activity, while the NHL repeat region mediates sequence-selective RNA binding. Regulation of TRIM71 occurs through transcriptional control, microRNA targeting, and protein-protein interactions. A TRIM71 antibody supports research applications focused on RNA biology, stem cell regulation, and post-transcriptional control mechanisms, with NSJ Bioreagents providing reagents intended for research use.
Optimal dilution of the TRIM71 antibody should be determined by the researcher.
E. coli-derived recombinant human protein (amino acids E85-F868) was used as the immunogen for the TRIM71 antibody.
After reconstitution, the TRIM71 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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