- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
TRIM29 Antibody for IHC / Tripartite motif-containing protein 29 [clone MSVA-629M] (V6077)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V6077-100UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 100 ug | 599.50 | |
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V6077-20UG | Antibody in 1X PBS with 0.05% BSA, 0.05% sodium azide | 20 ug | 324.50 |
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| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG2b, kappa |
| Clone Name | MSVA-629M |
| UniProt | Q14134 |
| Localization | Cytoplasm, Lysosome |
| Applications | Immunohistochemistry (FFPE) : 1:100-1:200 |
| Limitations | This TRIM29/Tripartite motif-containing protein 29 antibody is available for research use only. |
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Tripartite motif-containing protein 29 is an epithelial-associated TRIM family member encoded by the TRIM29 gene and also known as ATDC. The TRIM29 Antibody for IHC is developed to evaluate tissue-specific expression patterns of this regulatory protein in formalin-fixed, paraffin-embedded specimens. TRIM29 is located on chromosome 11q23 and encodes a scaffold-like protein characterized by B-box and coiled-coil domains, distinguishing it from many other TRIM proteins that contain canonical RING domains.
In normal tissues, TRIM29 expression is enriched in stratified and glandular epithelial compartments, including skin, esophagus, lung, and pancreas. Immunohistochemical studies have demonstrated predominant cytoplasmic and variable nuclear localization within epithelial cells, often with stronger staining in basal and suprabasal layers of squamous epithelium. This layered expression pattern reflects its role in epithelial differentiation and maintenance of structural integrity.
In oncologic research, TRIM29 expression has been observed in squamous cell carcinomas, pancreatic adenocarcinoma, gastric carcinoma, and other epithelial malignancies. Its expression profile can vary depending on tumor type, with reports describing associations with invasion, cellular stress adaptation, and epithelial remodeling. Because of its epithelial enrichment and context-dependent tumor expression, TRIM29 is frequently evaluated in tissue-based studies examining tumor classification and epithelial lineage biology.
As a tripartite motif family protein, TRIM29 participates in signaling networks that influence chromatin organization and cellular stress response pathways. Investigation of TRIM29 expression by immunohistochemistry supports research focused on epithelial differentiation, tumor-associated remodeling, and spatial distribution of regulatory proteins within tissue architecture. Clone MSVA-629M is a mouse monoclonal antibody developed to detect TRIM29 expression in histologic specimens.
1. Optimal dilution of the TRIM29 antibody for IHC should be determined by the researcher.
2. This TRIM29/Tripartite motif-containing protein 29 antibody is recombinantly produced by expression in CHO cells.
3. Manual Protocol: Freshly cut sections should be used (less than 10 days between cutting and staining). Heat-induced antigen retrieval for 5 minutes in an autoclave at 121oC in pH 7.8 Target Retrieval Solution buffer. Apply the antibody at a dilution of 1:150 at 37oC for 60 minutes. Visualization of bound antibody by the EnVision Kit (Dako, Agilent) according to the manufacturer's directions.
A recombinant fragment (126 amino acid residues between amino acids 1-200) of human TRIM29 protein was used as the immunogen for the TRIM29 antibody for IHC.
TRIM29/Tripartite motif-containing protein 29 antibody with sodium azide - store at 2 to 8oC; antibody without sodium azide - store at -20 to -80oC.
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