- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Trem2 Antibody / Triggering receptor expressed on myeloid cells 2 (RQ6214)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
|
RQ6214 | 0.5mg/ml if reconstituted with 0.2ml sterile DI water | 100 ug | 439 |
| Availability | 1-3 business days |
| Species Reactivity | Rat |
| Format | Antigen affinity purified |
| Clonality | Polyclonal (rabbit origin) |
| Isotype | Rabbit IgG |
| Purity | Affinity purified |
| Buffer | Lyophilized from 1X PBS with 2% Trehalose and 0.0125% sodium azide |
| UniProt | D3ZZ89 |
| Applications | Western Blot : 1-2ug/ml Flow Cytometry : 1-3ug/million cells Direct ELISA : 0.1-0.5ug/ml |
| Limitations | This Trem2 antibody is available for research use only. |
|
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TREM2 antibody is a useful tool for investigating myeloid cell function and neuroinflammation in rat systems. In rats, triggering receptor expressed on myeloid cells 2 (Trem2) is expressed by microglia, macrophages, and dendritic cells. Its signaling through the adaptor DAP12 promotes phagocytosis, lipid uptake, and cytokine regulation, making it critical for brain and immune homeostasis in rat experimental models.
Rat Trem2 expression has been studied in models of stroke, traumatic brain injury, and neurodegeneration. In these settings, Trem2 positive microglia accumulate at sites of injury where they clear cellular debris and limit inflammation. Impaired Trem2 signaling reduces phagocytic capacity and worsens neuronal damage, highlighting its protective role in the rat nervous system. Beyond the brain, Trem2 contributes to macrophage biology in peripheral organs, where it regulates lipid metabolism and tissue remodeling.
At the molecular level, rat Trem2 shares structural features with its human and mouse counterparts, including an extracellular immunoglobulin-like domain, a transmembrane region linked to DAP12, and a cytoplasmic tail. Signaling through DAP12 involves phosphorylation of ITAM motifs and activation of SYK, leading to downstream pathways that control cytoskeletal dynamics and cytokine production.
The TREM2 antibody is widely applied in rat tissues using immunohistochemistry, immunofluorescence, western blotting, and flow cytometry. These applications are essential for understanding microglial biology in injury models, studying chronic inflammation, and exploring metabolic processes in the rat. For scientists using rat systems to model human disease, the TREM2 antibody provides a specific and reliable reagent. NSJ Bioreagents supplies validated antibodies that deliver reproducibility and precision in advanced molecular studies.
Optimal dilution of the Trem2 antibody should be determined by the researcher.
A rat recombinant partial protein (amino acids L19-D131) was used as the immunogen for the Trem2 antibody.
After reconstitution, the Trem2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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