- Tel: 858.663.9055
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Email: info@nsjbio.com
- Tel: 858.663.9055
- Email: info@nsjbio.com
Transglutaminase 2 Antibody (FN Binding Domain) [clone TGM2/3612] (V9619)
Email: info@nsjbio.com
| Catalog No | Formulation | Size | Price (USD) | ||
|---|---|---|---|---|---|
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V9619-100UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 100 ug | 559 | |
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V9619-20UG | 0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide | 20 ug | 259 | |
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V9619SAF-100UG | 1 mg/ml in 1X PBS; BSA free, sodium azide free | 100 ug | 559 |
| Availability | 1-3 business days |
| Species Reactivity | Human |
| Format | Purified |
| Host | Mouse |
| Clonality | Monoclonal (mouse origin) |
| Isotype | Mouse IgG1, kappa |
| Clone Name | TGM2/3612 |
| Purity | Protein A/G affinity |
| UniProt | P21980 |
| Localization | Cytoplasm, Cell surface |
| Applications | Flow Cytometry : 1-2ug/million cells Immunofluorescence : 1-2ug/ml Immunohistochemistry (FFPE) : 1-2ug/ml |
| Limitations | This Transglutaminase 2 Antibody (FN Binding Domain) is available for research use only. |
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Transglutaminase 2 Antibody (FN Binding Domain) recognizes the fibronectin (FN) binding domain of Transglutaminase 2 (TGM2), a multifunctional enzyme that participates in calcium-dependent protein crosslinking as well as extracellular matrix organization and cell signaling. While TGM2 is best known for its transamidase activity, its interaction with fibronectin is equally important for mediating stable cell-matrix adhesion and maintaining tissue architecture. The fibronectin-binding domain enables Transglutaminase 2 to associate with extracellular matrix proteins independently of its enzymatic activity, supporting cell attachment, migration, and communication with the surrounding microenvironment. A Transglutaminase 2 Antibody (FN Binding Domain) provides a specialized tool for investigating this important functional region of the protein.
Transglutaminase 2 is widely expressed in epithelial cells, endothelial cells, fibroblasts, smooth muscle cells, platelets, and numerous additional tissues. Although predominantly cytoplasmic, the protein is also present on the cell surface and within the extracellular matrix, where it binds fibronectin, integrins, collagen, and other matrix components. These interactions contribute to extracellular matrix stabilization, basement membrane organization, wound healing, tissue repair, and regulation of cell adhesion. Because the fibronectin-binding domain mediates many of these extracellular functions, antibodies directed against this region are valuable for studies examining protein localization, matrix interactions, and adhesion-dependent signaling.
Abnormal Transglutaminase 2 expression or activity has been associated with fibrosis, cancer progression, cardiovascular disease, chronic inflammation, and autoimmune disorders including celiac disease. Increased extracellular TGM2 promotes matrix remodeling, epithelial-mesenchymal transition, tumor invasion, metastatic dissemination, and fibrotic tissue accumulation through enhanced interactions with fibronectin and other extracellular matrix proteins. The fibronectin-binding domain has therefore attracted significant interest as a regulator of tumor microenvironment remodeling and tissue fibrosis. A Transglutaminase 2 Antibody (FN Binding Domain) supports investigations into these disease-associated mechanisms by enabling researchers to study the extracellular functions of TGM2 independently of its catalytic activity.
Transglutaminase 2 antibodies are suitable for applications including Western blotting, immunohistochemistry, immunofluorescence, flow cytometry, immunoprecipitation, and related protein detection methods when validated for the specific application. Domain-specific antibodies are particularly useful for investigating protein-protein interactions involving fibronectin and other extracellular matrix components while complementing studies of total Transglutaminase 2 expression. NSJ Bioreagents provides carefully validated antibodies to support investigations of extracellular matrix biology, cell adhesion, fibrosis, cancer progression, and tissue remodeling. A Transglutaminase 2 Antibody (FN Binding Domain) is a valuable research reagent for detecting the fibronectin-binding region of Transglutaminase 2 and advancing studies of extracellular matrix organization, cell-matrix interactions, and disease-associated tissue remodeling.
Visit our TGM2 Antibody / Transglutaminase 2 Antibody page to explore additional validated antibodies and research tools for investigating TGM2 expression, extracellular matrix remodeling, cell adhesion, fibrosis, and cancer progression.
Optimal dilution of the Transglutaminase 2 Antibody (FN Binding Domain) should be determined by the researcher.
Recombinant full-length human TGM2 protein was used as the immunogen for the Transglutaminase 2 antibody.
Aliquot the Transglutaminase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Transglutaminase 2 (FN Binding Domain) antibody, TGM2 (FN Binding Domain) antibody, Tissue Transglutaminase (FN Binding Domain) antibody, TG2 (FN Binding Domain) antibody, Fibronectin Binding Domain Transglutaminase 2 antibody, Protein-glutamine Gamma-glutamyltransferase 2 (FN Binding Domain) antibody
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